The serotonin-2 receptor modulator, (-)-trans-PAT, decreases voluntary ethanol consumption in rats.
The serotonin-2 receptor modulator, (-)-trans-PAT, decreases voluntary ethanol consumption in rats.
复制标题
5-羟色胺-2 受体调节剂 (-)-trans-PAT 可减少大鼠的自愿乙醇消耗。
DOI：
10.1016/j.ejphar.2013.09.008
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发表时间：
2013
影响因子：
5
通讯作者：
Peris,Joanna
中科院分区：
文献类型：
--
作者：
Kasper,James;Tikamdas,Rajiv;Kim,MyongSang;Macfadyen,Kaley;Aramini,Richard;Ladd,Joseph;Bisceglia,Sarah;Booth,Raymond;Peris,Joanna
Serotonin (5-HT) 5-HT2Creceptor agonists have shown promise as novel alcoholism pharmacotherapies, but developing selective agonists has been problematic. Female Sprague Dawley rats were given ethanol in a palatable gel vehicle during operant sessions. 5-HT2Creceptor modulators (Ro60-0175, SB242,084, and (-)-trans-PAT) were administered before operant sessions. As a control for the effects of 5-HT2Creceptor agonism on caloric intake, drugs were also tested using non-ethanol containing gelatin. Ro60-0175, a 5-HT2family receptor agonist, decreased both ethanol and vehicle responding while (-)-trans-PAT, a 5-HT2Creceptor agonist with 5-HT2A-2Breceptor inverse agonist activity, selectively reduced only ethanol responding. The effect of 5-HT2Creceptor agonists on self-administration after reinstatement of ethanol after a three week deprivation was also determined. (-)-trans-PAT eliminated increases in ethanol intake following ethanol deprivation whereas Ro60-0175 had no effect. These results emphasize the need for caloric controls and further support the idea that selective modulation of 5-HT2family receptors is a potential pharmacotherapeutic approach in the treatment of alcoholism.
