Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting
Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting
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DOI：
10.1093/scan/nsn004
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发表时间：
2008-06-01
影响因子：
4.2
通讯作者：
van IJzendoorn, Marinus H.
中科院分区：
文献类型：
--
作者：
Bakermans-Kranenburg, Marian J.;van IJzendoorn, Marinus H.
催产素和5-羟色胺都能调节对伴侣和后代的亲和反应。动物研究表明，催产素在哺乳动物的分娩和哺乳过程中起着至关重要的作用，而且在养育子女和与后代的社会互动中也起着重要作用。多巴胺能系统也可能通过影响情绪和催产素的释放而发挥重要作用。我们研究了5-羟色胺转运体（5-HTT）和催产素受体（OXTR）基因在解释159名白人中产阶级母亲的社区样本中的敏感养育差异中的作用，考虑到母亲的教育水平，母亲的抑郁症和婚姻关系的质量，他们的2岁幼儿有外化行为问题的风险。5-HTTLPR SCL 6A 4和OXTR rs 53576对观察到的母亲敏感性的独立遗传效应被发现。控制母亲教育、抑郁和婚姻不和的差异，具有可能效率较低的多巴胺能（5-HTT ss）和催产素能（AA/ AG）系统基因变体的父母对他们的幼儿表现出较低水平的敏感反应。与婚姻不和或抑郁症的双向和三向互动不显着。这项关于OXTR和5-HTT基因在人类养育中的作用的首次研究指出，可能与催产素产生有关的分子遗传差异解释了敏感养育的差异。
Both oxytocin and serotonin modulate affiliative responses to partners and offspring. Animal studies suggest a crucial role of oxytocin in mammalian parturition and lactation but also in parenting and social interactions with offspring. The serotonergic system may also be important through its influence on mood and the release of oxytocin. We examined the role of serotonin transporter ( 5-HTT) and oxytocin receptor ( OXTR) genes in explaining differences in sensitive parenting in a community sample of 159 Caucasian, middle-class mothers with their 2-year-old toddlers at risk for externalizing behavior problems, taking into account maternal educational level, maternal depression and the quality of the marital relationship. Independent genetic effects of 5-HTTLPR SCL6A4 and OXTR rs53576 on observed maternal sensitivity were found. Controlling for differences in maternal education, depression and marital discord, parents with the possibly less efficient variants of the serotonergic ( 5-HTT ss) and oxytonergic ( AA/ AG) system genes showed lower levels of sensitive responsiveness to their toddlers. Two-way and three-way interactions with marital discord or depression were not significant. This first study on the role of both OXTR and 5-HTT genes in human parenting points to molecular genetic differences that may be implicated in the production of oxytocin explaining differences in sensitive parenting.