Inhibitory activity of phosphorylated chitooligosaccharides on the formation of calcium phosphate
Inhibitory activity of phosphorylated chitooligosaccharides on the formation of calcium phosphate
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DOI：
10.1016/j.carbpol.2005.03.014
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发表时间：
2005-06-20
影响因子：
11.2
通讯作者：
Cho, YI
中科院分区：
文献类型：
--
作者：
Kim, SK;Park, PJ;Cho, YI
采用超滤膜生物反应器系统制备壳寡糖（cos），分别命名为cos -1 （10-5 kDa）、cos - 2 （5-3 kDa）、cos -3 （3-1 kDa）和cos - 4（低于1 kDa）。此外，在甲磺酸溶液中用P(2)O(5)法制备了它们的磷酸化衍生物，并对磷酸化壳寡糖不溶性磷酸钙的形成有抑制作用。磷酸化COS-IV对磷酸钙沉淀的抑制活性最高。其抑制活性与CPP相似，特别是在浓度大于4 mg/ml时，CPP被广泛用作钙强化剂，提高钙的吸收能力。因此，磷酸化的壳寡糖可能是磷酸钙沉淀的潜在抑制剂。(c) 2005 Elsevier Ltd版权所有。
Chitooligosaccharides (COSs) were successfully prepared using an ultrafiltration membrane bioreactor system, and named as COS-I (10-5 kDa), COS-II (5-3 kDa), COS-III (3-1 kDa), and COS-IV (below I kDa), respectively. In addition, their phosphorylated derivatives were prepared by a P(2)O(5) in methanesulfonic acid solution, and inhibitory activity on the formation of insoluble calcium phosphate of phosphorylated chitooligosaccharides. Phosphorylated COS-IV exhibited the highest inhibitory activity of calcium phosphate precipitation among tested chitooligosaccharides. Its inhibitory activity, especially at the concentration more than 4 mg/ml, was similar to that of CPP, which is widely used as a calcium fortifying agent increasing calcium absorbability. Therefore, phosphorylated chitooligosaccharides may be potential inhibitors of calcium phosphate precipitation. (c) 2005 Elsevier Ltd. All rights reserved.