Herpes simplex virus type 2-specific CD8 cytotoxic T lymphocyte cross-reactivity against prevalent HLA class I alleles
Herpes simplex virus type 2-specific CD8 cytotoxic T lymphocyte cross-reactivity against prevalent HLA class I alleles
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DOI：
10.1182/blood.v99.10.3844
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发表时间：
2002-05-15
期刊：
影响因子：
20.3
通讯作者：
Petersdorf, EW
中科院分区：
文献类型：
--
作者：
Koelle, DM;Chen, HBB;Petersdorf, EW
Clonally expressed T-cell receptor alphabeta heterodimers are able to bind many different major histocompatibility complex/peptide combinations. This promiscuity is thought to be required for adequate surveillance against microbial and malignancy-associated antigens. After transplantation, T cells may react with nonself structures, contributing to graft-versus-host disease, in the case of hematopoietic stem cell transplantation, or graft failure, when the host Immune system is preserved. We describe 2 distinct HLA A*0201-restricted, cytotoxic CD8 T-cell responses to the prevalent chronic pathogen, herpes simplex virus type 2, that cross-react with cells bearing specific alleles of the common HLA B44 family. Transfection of human or primate renal epithelial cells with HLA class I complementary DNA confirmed these results. Given the prevalence of this viral Infection and the HLA alleles Involved, it Is possible that this cross-reactivity may be Involved in clinically significant events. (C) 2002 by The American Society of Hematology.
