Insulin resistance is associated with increased serum levels of glycosylphosphatidylinositol-specific phospholipase D
Insulin resistance is associated with increased serum levels of glycosylphosphatidylinositol-specific phospholipase D
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DOI：
10.1016/j.metabol.2003.09.004
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发表时间：
2004-02-01
影响因子：
9.8
通讯作者：
Deeg, MA
中科院分区：
文献类型：
--
作者：
Kurtz, TA;Fineberg, NS;Deeg, MA
代谢综合征的血脂异常与甘油三酯和高密度脂蛋白（HDL）代谢的改变有关。我们在一个胰岛素敏感性范围广泛的队列中检测了糖基磷脂酰肌醇特异性磷脂酶D（GPI-PLD）的血清水平，GPI-PLD是一种次要的HDL相关蛋白。109名受试者的平均血清GPI-PLD质量为58.9 +/- 18.4 mug/mL（平均值+/- SD）。GPI-PLD水平与胆固醇、载脂蛋白A1、甘油三酯、胰岛素和稳态模型评估（HOMA）直接相关，但与C反应蛋白无关。提示血清GPI-PLD升高与胰岛素抵抗有关。(C)2004爱思唯尔公司All rights reserved.
The dyslipidemia of the metabolic syndrome is associated with alterations in triglyceride and high-density lipoprotein (HDL) metabolism. We examined the serum levels of glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD), a minor HDL-associated protein, in a cohort with a wide range of insulin sensitivity. The mean serum GPI-PLD mass from 109 subjects was 58.9 +/- 18.4 mug/mL (mean +/- SD). GPI-PLD levels directly correlated with cholesterol, apolipoprotein Al, triglycerides, insulin, and homeostasis model assessment (HOMA) but not C-reactive protein. These results suggest that increased serum GPI-PLD is associated with the insulin resistance. (C) 2004 Elsevier Inc. All rights reserved.