Chemosensory deficits are best predictor of serologic response among individuals infected with SARS-CoV-2.
Chemosensory deficits are best predictor of serologic response among individuals infected with SARS-CoV-2.
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DOI：
10.1371/journal.pone.0274611
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Chiuzan C
中科院分区：
文献类型：
--
作者：
Overdevest JB;Irace AL;Mazzanti V;Oh EJ;Joseph PV;Devanand DP;Bitan ZC;Hod EA;Gudis DA;Chiuzan C
味觉和味觉改变与SARS-CoV-2感染密切相关，并可能与更缓慢的病程有关。轻度疾病个体的血清学应答率仍然有限。我们试图确定与COVID-19相关的化学感受性变化是否可预测血清学反应。横断面研究。样本由306名成年人（≥18岁）组成，他们于2020年4月至6月期间在感知COVID-19疾病后自愿捐献恢复期血浆。在血清学分析时记录COVID-19 PCR状态、患病时的临床症状和治疗过程，我们使用患者感知的缺陷评估化学感觉功能。我们实施了先前验证的ELISA筛查，以确定抗刺突免疫球蛋白的血清学状态。采用逐步logistic模型进行统计分析，以确定血清学应答的预测因素。在接受血清学和化学感觉评估的306名患者中，196名（64.1%）和195名（63.7%）分别报告了COVID-19感染前两周内的主观嗅觉和味觉功能障碍。在未调整的模型中，与嗅觉和味觉正常的人相比，嗅觉改变的人（95% CI 1.14-3.42，p = 0.014）和味觉改变的人（95% CI 1.17-3.48，p = 0.011）中出现阈上IgG抗体滴度的几率分别高出1.98倍和2.02倍。调整性别、年龄、人种/种族、症状持续时间、吸烟状态和合并症指数的多变量logistic模型表明，嗅觉和味觉的改变仍然是阳性抗刺突IgG应答的重要预测因素。（嗅觉OR = 1.90，95%CI 1.05-3.44，p = 0.033;味觉OR = 2.01，95%CI = 1.12-3.61，p = 0.019）。主观化学感觉功能障碍，如自我报告的嗅觉或味觉缺陷，高度预测SARS-CoV-2感染后的血清学反应。这些信息可能对患者咨询有用。应进行额外的纵向研究，以更好地了解这些患者血清学应答的发生和持续时间。
Smell and taste alteration are closely linked to infection with SARS-CoV-2 and may be associated with a more indolent disease course. Serologic response rates among individuals with mild disease remains limited. We sought to identify whether chemosensory changes associated with COVID-19 were predictive of a serologic response. Cross-sectional study. The sample consisted of 306 adults (≥18 years old) volunteering for convalescent plasma donation following perceived COVID-19 illness from April-June 2020. Documentation of COVID-19 PCR status, clinical symptoms at time of illness, and treatment course occurred at the time of serologic analysis, where we assessed chemosensory function using patient-perceived deficits. We implemented previously validated ELISA screening to determine serologic status regarding anti-Spike immunoglobulins. Statistical analysis using stepwise logistic models were employed to identify predictive factors of serologic response. Of 306 patients undergoing serologic and chemosensory evaluation, 196 (64.1%) and 195 (63.7%) reported subjective olfactory and taste dysfunction, respectively, during the first two weeks of COVID-19 infection. In unadjusted models, the odds of developing suprathreshold IgG antibody titers were 1.98 times higher among those who reported altered smell (95% CI 1.14–3.42, p = 0.014) and 2.02 times higher among those with altered taste (95% CI 1.17–3.48, p = 0.011) compared to those with normal smell and taste. Multivariable logistic models adjusting for sex, age, race/ethnicity, symptom duration, smoking status and comorbidities index demonstrated that altered smell and taste remained significant predictors of positive anti-spike IgG response (smell OR = 1.90, 95% CI 1.05–3.44, p = 0.033; taste OR = 2.01, 95% CI = 1.12–3.61, p = 0.019). Subjective chemosensory dysfunction, as self-reported smell or taste deficiency, is highly predictive of serologic response following SARS-CoV-2 infection. This information may be useful for patient counseling. Additional longitudinal research should be performed to better understand the onset and duration of the serologic response in these patients.
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DOI：
10.1016/s2213-2600(21)00407-0
发表时间：
2021-12
期刊：
The Lancet. Respiratory medicine
影响因子：
--
作者：
Milne G;Hames T;Scotton C;Gent N;Johnsen A;Anderson RM;Ward T
通讯作者：
Ward T
影响因子：
4.1
作者：
Shields AM;Faustini SE;Perez-Toledo M;Jossi S;Allen JD;Al-Taei S;Backhouse C;Dunbar LA;Ebanks D;Emmanuel B;Faniyi AA;Garvey M;Grinbergs A;McGinnell G;O'Neill J;Watanabe Y;Crispin M;Wraith DC;Cunningham AF;Drayson MT;Richter AG
通讯作者：
Richter AG
影响因子：
13.6
作者：
通讯作者：
--
影响因子：
2.6
作者：
Saniasiaya, Jeyasakthy;Islam, Md Asiful;Abdullah, Baharudin
通讯作者：
Abdullah, Baharudin
DOI：
10.1016/s2213-2600(21)00158-2
发表时间：
2021-07
期刊：
The Lancet. Respiratory medicine
影响因子：
--
作者：
Letizia AG;Ge Y;Vangeti S;Goforth C;Weir DL;Kuzmina NA;Balinsky CA;Chen HW;Ewing D;Soares-Schanoski A;George MC;Graham WD;Jones F;Bharaj P;Lizewski RA;Lizewski SE;Marayag J;Marjanovic N;Miller CM;Mofsowitz S;Nair VD;Nunez E;Parent DM;Porter CK;Santa Ana E;Schilling M;Stadlbauer D;Sugiharto VA;Termini M;Sun P;Tracy RP;Krammer F;Bukreyev A;Ramos I;Sealfon SC
通讯作者：
Sealfon SC