Insights into SEN virus prevalence, transmission, and treatment in community-based persons and patients with liver disease referred to a liver disease unit.
Insights into SEN virus prevalence, transmission, and treatment in community-based persons and patients with liver disease referred to a liver disease unit.
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深入了解 SEN 病毒在社区人群和转诊至肝病科的肝病患者中的流行、传播和治疗。
DOI：
10.1086/342329
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
G. Minuk
中科院分区：
文献类型：
--
作者：
Stephen G Wong;D. Primi;H. Kojima;A. Sottini;A. Giulivi;Manna Zhang;J. Uhanova;G. Minuk
为了记录SEN病毒（SEN-V）在社区个人和肝病单位患者中的传播途径和流行率，通过聚合酶链反应检测了从160名加拿大因纽特人和140名肝病患者中获得的储存血清样本的SEN-V DNA。在社区人群中，160人中有57人（36%）存在SEN-V。SEN-V阳性个体往往更年轻，而且往往是男性。SEN-V阳性和SEN-V阴性个体的肝酶水平和甲型和B型肝炎病毒血清学标志物相似。140例肝病患者中有30例（21%）存在SEN-V。SEN-V阳性和SEN-V阴性患者的年龄、性别、病毒获得的危险因素、症状的患病率以及肝脏生化和组织学检查结果相似。这些结果表明，SEN-V感染是健康个体和慢性肝病患者中常见的病毒感染，传播可能通过非肠道途径发生，并且SEN-V感染与既存肝病患者的更高或更严重的肝病发病率无关。
To document the prevalence and routes of transmission of SEN virus (SEN-V) in community-based individuals and patients referred to a liver disease unit, stored serum samples obtained from 160 Canadian Inuit and 140 patients with liver disease were tested for SEN-V DNA by polymerase chain reaction. In the community-based population, SEN-V was present in 57 (36%) of 160 persons. SEN-V-positive individuals tended to be younger and were more often male. Liver enzyme levels and serologic markers for hepatitis A and B viruses were similar in SEN-V-positive and SEN-V-negative individuals. SEN-V was present in 30 (21%) of the 140 patients with liver disease. Age, sex, risk factors for viral acquisition, prevalence of symptoms, and liver biochemical and histological findings were similar in SEN-V-positive and SEN-V-negative patients. These results indicate that SEN-V infection is a common viral infection in both healthy individuals and patients with chronic liver disease, that transmission likely occurs via nonparenteral routes, and that SEN-V infection is not associated with higher rates of or more-severe liver disease in persons with preexisting liver disease.