Neuropharmacological actions of cigarette smoke: Brain monoamine oxidase B (MAO B) inhibition
Neuropharmacological actions of cigarette smoke: Brain monoamine oxidase B (MAO B) inhibition
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DOI：
10.1300/j069v17n01_03
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发表时间：
1998-01-01
影响因子：
2.3
通讯作者：
Zezulkova, I
中科院分区：
文献类型：
--
作者：
Fowler, JS;Volkow, ND;Zezulkova, I
我们用正电子发射断层扫描和放射性示踪剂[C-11]L-异丙烯基([C-11]L-异丙烯基-D2)测定了8名吸烟者脑单胺氧化酶B(MAO B；EC 1.4.3.4)的浓度，并与8名非吸烟者和4名戒烟者进行了比较。在所有大脑区域都观察到了减少。吸烟者的低脑MAO B似乎是一种药理学效应，而不是遗传效应，因为既往吸烟者与不吸烟者没有区别。吸烟对大脑MAO B的抑制作用与吸烟和帕金森氏症之间的负相关以及吸烟在精神障碍和药物滥用中的高流行率之间存在相关性。虽然尼古丁是烟草烟雾神经药理作用的核心，但MAO B抑制也可能是理解和治疗烟草烟雾成瘾的一个重要变量。
We measured the concentration of brain monoamine oxidase B (MAO B; EC 1.4.3.4) in 8 smokers and compared it with that in 8 non-smokers and in 4 former smokers using positron emission tomography (PET) and deuterium substituted [C-11]l-deprenyl ([C-11]L-deprenyl-D2) as a radiotracer for MAO B. Smokers had significantly lower brain MAO B than non-smokers as measured by the model term lambda k(3) which is a function of MAO B activity. Reductions were observed in all brain regions. Low brain MAO B in the cigarette smoker appears to be a pharmacological rather than a genetic effect since former smokers did not differ from non-smokers. Brain MAO B inhibition by cigarette smoke is of relevance in light of the inverse association between smoking and Parkinson's disease and a high prevalence of smoking in psychiatric disorders and in substance abuse. Though nicotine is at the core of the neuropharmacological actions of tobacco smoke, MAO B inhibition may also be an important variable in understanding and treating tobacco smoke addiction.