Severity of tuberculosis in mice is linked to distal chromosome 3 and proximal chromosome 9
Severity of tuberculosis in mice is linked to distal chromosome 3 and proximal chromosome 9
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DOI：
10.1086/314843
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发表时间：
1999-07-01
影响因子：
6.4
通讯作者：
Schurr, E
中科院分区：
文献类型：
--
作者：
Lavebratt, C;Apt, AS;Schurr, E
遗传因素在宿主对结核分枝杆菌感染的反应中发挥作用，结核分枝杆菌是全球头号传染病杀手。在静脉注射致死剂量的人类结核分枝杆菌H37Rv毒株后，近交系菌株I/ST和A/SN的小鼠在疾病严重程度上显示出显著的差异。用N37Rv攻击后，只有I/ST小鼠体重下降迅速，存活时间短。对(A/SnxI/ST)F1×I/ST小鼠进行了结核分枝杆菌N37Rv感染后与体重连锁的全基因组分析。在女性中，第9和第3染色体上的数量性状座位(QTL)与感染后体重显著相关(优势比(LOD)的对数分别为6.68和3.92)，第8和第17染色体上的QTL与感染后体重显著相关(LOD分别为3.01和2.95)。对于男性，位于第5和第10染色体上的QTL显示出暗示连锁(LOD分数分别为3.03和2.31)。这些联系可用于确定人类基因组中结核病易感基因的候选区域。
Genetic factors play a role in host response to infection with Mycobacterium tuberculosis, the number one infectious killer worldwide. Mice of the inbred strains I/St and A/Sn show significant differences in disease severity after intravenous injection of a lethal dose of the virulent human isolate M. tuberculosis H37Rv. Following challenge with N37Rv, only I/St mice have rapid body weight loss and short survival times. A genome wide analysis for linkage with body weight after M. tuberculosis N37Rv infection was done in (A/Sn x I/St)F1 x I/St mice. Among females, quantitative trait loci (QTLs) on chromosomes 9 and 3 were significantly linked to postinfection body weight (logarithm of the odds ratio [LOD] scores of 6.68 and 3.92, respectively), Suggestive linkages were found for QTLs on chromosomes 8 and 17 (LOD scores of 3.01 and 2.95, respectively). For males, QTLs on chromosomes 5 and 10 showed suggestive linkages (LOD scores of 3.03 and 2.31, respectively). These linkages can be used to identify candidate regions for tuberculosis susceptibility loci in the human genome.