SWINE INFLUENZA LIKE VIRUSES IN TURKEYS - POTENTIAL SOURCE OF VIRUS FOR HUMANS
SWINE INFLUENZA LIKE VIRUSES IN TURKEYS - POTENTIAL SOURCE OF VIRUS FOR HUMANS
复制标题
DOI：
10.1126/science.6298942
复制
发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
SENNE, DA
中科院分区：
文献类型：
--
作者：
HINSHAW, VS;WEBSTER, RG;SENNE, DA
最近从美国不同地区的火鸡中分离出的甲型流感病毒（H1N1亚型）被确定与通常与猪相关的毒株密切相关。这一结论是基于猪、人、鸭和火鸡的H1N1分离株与多克隆和单克隆抗体、RNA-RNA竞争性杂交和复制研究的比较。其中一个从火鸡身上分离的H1N1病毒引起了一名实验室技术人员的流感，他表现出发热、呼吸道疾病、病毒脱落和血清转化。这些结果表明，火鸡和猪都参与了这些病毒的维持及其向人类的传播。
Influenza A viruses (subtype H1N1), recently isolated from turkeys in different areas of the United States, were determined to be closely related to strains typically associated with pigs. This conclusion was based on comparisons of H1N1 isolates from pigs, humans, ducks, and turkeys with polyclonal and monoclonal antibodies, RNA-RNA competitive hybridization, and replication studies. One of the H1N1 isolates from turkeys caused influenza in a laboratory technician, who displayed fever, respiratory illness, virus shedding, and seroconversion. These results suggest that turkeys as well as pigs are involved in the maintenance of these viruses and their transmission to humans.