Myeloid-Derived Suppressor Cells Mediate Inflammation Resolution in Humans and Mice with Autoimmune Uveoretinitis
Myeloid-Derived Suppressor Cells Mediate Inflammation Resolution in Humans and Mice with Autoimmune Uveoretinitis
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DOI：
10.4049/jimmunol.1700617
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发表时间：
2018-02-15
影响因子：
4.4
通讯作者：
Oh, Joo Youn
中科院分区：
文献类型：
--
作者：
Jeong, Hyun Jeong;Lee, Hyun Ju;Oh, Joo Youn
炎症的消退是一个导致组织动态平衡的活跃过程，涉及多种细胞和分子机制。髓系来源的抑制细胞(MDSCs)由于具有抑制T细胞活化的活性，近年来已成为消退炎症的重要细胞成分。在本文中，我们发现在自身免疫性葡萄膜视网膜炎缓解期和缓解前，患者和小鼠的人类MDSCs和CD11b(+)Ly6G2 Ly6C(+)小鼠MDSCs显著增加。从自身免疫性葡萄膜视网膜炎小鼠分离的CD11b(+)Ly6C(+)单核细胞在体外能抑制T细胞的增殖，过继转移该细胞可加速自身免疫性葡萄膜视网膜炎的缓解。或者，CD11b(+)Ly6C(+)单核细胞在解决期的耗尽，而不是CD11b(+)Ly6G(+)粒细胞的耗尽，加剧了疾病。这些发现共同表明，单核细胞间充质干细胞作为调节细胞，介导自身免疫性葡萄膜视网膜炎的解决。
Resolution of inflammation is an active process that leads to tissue homeostasis and involves multiple cellular and molecular mechanisms. Myeloid-derived suppressor cells (MDSCs) have recently emerged as important cellular components in the resolution of inflammation because of their activities to suppress T cell activation. In this article, we show that HLA-DR2CD11b(+)CD33(+) CD14(+) human MDSCs and CD11b(+) Ly6G 2 Ly6C(+) mouse MDSCs markedly increased in patients and mice during and before the resolution phase of autoimmune uveoretinitis. CD11b(+) Ly6C(+) monocytes isolated from autoimmune uveoretinitis mice were able to suppress T cell proliferation in culture, and adoptive transfer of the cells accelerated the remission of autoimmune uveoretinitis in mice. Alternatively, depletion of CD11b(+)Ly6C(+) monocytes at the resolution phase, but not CD11b(+)Ly6G(+) granulocytes, exacerbated the disease. These findings collectively indicate that monocytic MDSCs serve as regulatory cells mediating the resolution of autoimmune uveoretinitis.