Expression Pattern and Prognostic Utility of PME-I in Patients with Hepatocellular Carcinoma
Expression Pattern and Prognostic Utility of PME-I in Patients with Hepatocellular Carcinoma
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PME-I 在肝细胞癌患者中的表达模式和预后效用
DOI：
10.2147/cmar.s252873
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发表时间：
2020-01-01
影响因子：
3.3
通讯作者：
Zhang, Sheng
中科院分区：
文献类型：
--
作者：
Du, Baoying;Liao, Hongfeng;Zhang, Sheng
目的：肝细胞癌是最常见的恶性肿瘤之一。同时，缺乏能够预测哪些患者有侵袭性病程风险的标记。虽然已经报道了一些蛋白磷酸酶甲酯酶-1(PME-1)的促肿瘤机制，但PME-1在包括肝癌发生发展在内的肿瘤中的作用仍不清楚。本研究的目的是探讨PME-1在肝细胞癌组织中的表达模式及其与病理参数的关系。用卡方检验确定PME-1染色与肝细胞癌患者临床病理变量的关系。用Kaplan-Meier分析和COX回归分析分别绘制生存曲线和验证影响预后的独立因素。结果：我们发现Pme-1在肝癌组织中的表达显著高于非肿瘤组织(P<；0.001)。此外，PME-1高表达与肿瘤分化程度(P=0.047)、肿瘤数目(P=0.001)、肝内外转移(P=0.018)和复发(P=0.001)显著相关。Kaplan-Meier分析显示，PME-1高表达与生存期缩短相关(P<；0.001)。单因素分析显示PME-1表达状态与总生存期显著相关(P<；0.001)。COX比例风险分析多因素模型显示Pme-1高表达是肝癌患者预后不良的独立预测因素(风险比3.429；95%可信区间1.369~8.589；P=0.009)。结论：Pme-1高表达与肝癌侵袭性病理特征和肿瘤预后相关，提示Pme-1高表达对肝癌患者有潜在的治疗价值。
Purpose: Hepatocellular carcinoma (HCC) remains one of the most common malignancies. While there is lack of markers capable of predicting which patients are at risk of aggressive course of the disease. Although a few protein phosphatase methyl-esterase-1 (PME-1) tumor-promoting mechanisms have been reported, the role of PME-1 in cancer including HCC occurrence and progression remains to be elucidated. The aim of this study was to explore the expression pattern and relationship between PME-1 with the pathological parameters in patients with HCC.Methods: PME-1 expression was assessed from HCC tissue chips via immunohistochemistry. Chi-square test was used to identify the association between PME-1 staining and clinicopathological variables of HCC patients. Kaplan-Meier analysis and Cox regression analysis were performed to draw survival curves and verify the independent prognostic factors of HCC patients, respectively.Results: We found that PME-1 expression was significantly higher in HCC tumor tissues compared with non-tumor tissues (P < 0.001). Furthermore, high expression level of PME-1 was significantly associated with differentiation (P = 0.047), tumor number (P = 0.001), intrahepatic or extrahepatic metastasis (P = 0.018), and recurrence (P = 0.001). Kaplan-Meier analysis revealed that high expression level of PME-1 was associated with shorter survival (P < 0.001). Univariate analysis with Log-rank test revealed that PME-1 expression status was significantly correlated with overall survival (P < 0.001). Furthermore, multivariate models with Cox proportional hazards analysis showed that high expression of PME-1 was a statistically independent predictive factor of poor prognosis in HCC patients (hazard ratio, 3.429; 95% confidence interval, 1.369-8.589; P = 0.009).Conclusion: In conclusion, these findings indicated that PME-1 expression was associated with aggressive pathological features and worse oncological outcomes, suggesting its potential therapeutic value for patients with HCC.