Practical resources for enhancing the reproducibility of mechanistic modeling in systems biology
Practical resources for enhancing the reproducibility of mechanistic modeling in systems biology
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DOI：
10.1016/j.coisb.2021.06.001
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发表时间：
2021-09-01
影响因子：
3.7
通讯作者：
Sauro, Herbert M.
中科院分区：
文献类型：
--
作者：
Blinov, Michael L.;Gennari, John H.;Sauro, Herbert M.
虽然可重复性是科学方法的核心原则，但重复许多结果仍然具有挑战性。Tiwari等人最近发现，他们只能重复系统生物学中50%的已发表模拟结果。我们确定了一些资源，研究人员可以利用这些资源使他们的研究更容易获得，可执行和被他人理解。增强的可重复性将加速更复杂模型的开发，这些模型可以为精准医学和合成生物学提供信息。
Although reproducibility is a core tenet of the scientific method, it remains challenging to reproduce many results. Tiwari et al. recently found that they could only repeat 50% of published simulation results in systems biology. We identified several resources that investigators can leverage to make their research more accessible, executable, and comprehensible by others., Enhanced reproducibility would accelerate the development of more sophisticated models that could inform precision medicine and synthetic biology.