SEX-DIFFERENCES IN GROWTH-PATTERNS OF THE AIRWAYS AND LUNG PARENCHYMA IN CHILDREN
SEX-DIFFERENCES IN GROWTH-PATTERNS OF THE AIRWAYS AND LUNG PARENCHYMA IN CHILDREN
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DOI：
10.1152/jappl.1984.56.5.1204
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发表时间：
1984-01-01
影响因子：
3.3
通讯作者：
TAUSSIG, LM
中科院分区：
文献类型：
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作者：
PAGTAKHAN, RD;BJELLAND, JC;TAUSSIG, LM
17名男孩和19名女孩，年龄8-15岁，在两个性别组中，确定预测气道大小的因素[通过测量气管横截面积(CSA)和最大呼气流量(Vmax)]以及主要呼吸道分支和肺实质的相对增长率。在男孩中，总肺活量(TLC)解释了CsA变异的77%，解释了ovrhdot.Vmax变异的66%。女孩的躯体生长和成熟仅占CSA变异的45%，对.ovrhdo.Vmax变异的解释为%；TLC相对不重要。在男孩中，但在女孩中，TLC校正的CSA与身高和TLC显著负相关。在女孩中，用力肺活量的50%和75%的TLC校正的.ovrhdot.Vmax与身高直接相关。两性间存在明显不同的呼吸道-实质-躯体生长关系。此外，实质生长似乎是男孩呼吸道生长的最佳决定因素。在女孩身上，除了实质的生长外，其他因素，可能是遗传因素，可能有助于决定呼吸道大小。
Seventeen boys and 19 girls, 8-15 yr in age, were studied to ascertain, in the 2 sex groups, the predictors of airway size [assessed by measurement of tracheal cross-sectional area (CSA) and maximal expiratory flows (.ovrhdot.Vmax)] and the relative rates of growth of the major divisions of the airways and lung parenchyma. In boys, total lung capacity (TLC) accounted for 77% of the variance of CSA and for 66% of the variability of .ovrhdot.Vmax. Somatic growth and maturation in girls accounted for only 45% of the variance of CSA and for 64% of the variability of .ovrhdot.Vmax; TLC was relatively unimportant. In boys, but not in girls, TLC-corrected CSA was significantly and inversely related to height and to TLC. In girls, TLC-corrected .ovrhdot.Vmax at 50 and 75% of forced vital capacity were directly related to height. Different patterns of airway-parenchymal-somatic growth relationships evidently exist in the 2 sexes. Furthermore, parenchymal growth appears to be the best determinant of airway growth in boys. In girls, other factors, perhaps genetic in nature, besides growth of parenchyma, may help determine airway size.