Influence of upper airway pressure changes on genioglossus muscle respiratory activity.
Influence of upper airway pressure changes on genioglossus muscle respiratory activity.
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上气道压力变化对颏舌肌呼吸活动的影响。
DOI：
10.1152/jappl.1982.52.2.438
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Thach,BT
中科院分区：
文献类型：
--
作者：
Mathew,OP;Abu-Osba,YK;Thach,BT
在20只麻醉家兔上观察了咽气道压力变化对咽扩张肌（颏舌肌）肌电图（EMG）活动的影响。在迷走神经切断的动物中，上气道负荷动作（鼻闭塞）增加了第一次闭塞呼吸时颏舌肌（GG）的吸气活动峰值。相反，“卸载”操作（从鼻呼吸切换到气管切开呼吸）降低了GG活性。为了进一步表征GG反应，在隔离的上气道内产生持续的压力变化。负压力增加GG活动，正压力降低it.A刺激后的影响，包括增加GG活动与对照组相比，被认为是负，正压力刺激后。周期性的压力变化施加到孤立的上气道增加GG活性。这些观察结果表明，存在反射途径，调节GG肌肉活动，以响应上气道压力负荷。该反射系统似乎在潮式呼吸期间调节GG活动中起作用，并且在确保咽气道通畅中可能是重要的。
The effects of change in pharyngeal airway pressure on electromyographic (EMG) activity of a pharyngeal dilating muscle (genioglossus) were investigated in 20 anesthetized rabbits. In vagotomized animals, upper airway loading maneuvers (nasal occlusion) increased the peak inspiratory activity of the genioglossus (GG) muscle on the first occluded breath. In contrast, “unloading” maneuvers (switching from nose to tracheostomy breathing) decreased GG activity. To further characterize the GG response, sustained pressure changes were produced within the isolated upper airway. Negative pressure increased GG activity; positive pressure decreased it. A poststimulus effect consisting of increased GG activity compared with control was seen following both negative- and positive-pressure stimuli. Cyclical pressure changes applied to the isolated upper airway increased the GG activity. These observations indicate the presence of reflex pathways that regulate GG muscle activity in response to upper airway pressure loads. This reflex system appears to play a role in regulating GG activity during tidal breathing and could be important in ensuring pharyngeal airway patency.