PlGF-MMP-9-expressing cells restore microcirculation and efficacy of cell therapy in aged dystrophic muscle
PlGF-MMP-9-expressing cells restore microcirculation and efficacy of cell therapy in aged dystrophic muscle
复制标题
DOI：
10.1038/nm.1852
复制
发表时间：
2008-09-01
期刊：
影响因子：
82.9
通讯作者：
Cossu, Giulio
中科院分区：
文献类型：
--
作者：
Gargioli, Cesare;Coletta, Marcello;Cossu, Giulio
硬化和微血管密度降低是肌营养不良晚期的特征，阻碍细胞或基因的传递，使大多数杜氏肌营养不良患者无法治疗。表达血管生成因子（胎盘生长因子，PlGF）和金属蛋白酶（基质金属蛋白酶-9，MMP-9）的改良肌腱成纤维细胞能够恢复血管网络并减少胶原沉积，从而对老年营养不良小鼠进行有效的细胞治疗。这些数据开启了将新疗法扩展到目前无法治疗的个体的可能性。
Sclerosis and reduced microvessel density characterize advanced stages of muscular dystrophy and hamper cell or gene delivery, precluding treatment of most individuals with Duchenne muscular dystrophy. Modified tendon fibroblasts expressing an angiogenic factor (placenta growth factor, PlGF) and a metalloproteinase (matrix metalloproteinase-9, MMP-9) are able to restore a vascular network and reduce collagen deposition, allowing efficient cell therapy in aged dystrophic mice. These data open the possibility of extending new therapies to currently untreatable individuals.