Performance of a 3-bladed propeller pump to provide cavopulmonary assist in the failing Fontan circulation
Performance of a 3-bladed propeller pump to provide cavopulmonary assist in the failing Fontan circulation
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DOI：
10.1016/j.athoracsur.2008.06.026
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发表时间：
2008-10-01
影响因子：
4.6
通讯作者：
Rodefeld, Mark D.
中科院分区：
文献类型：
--
作者：
Throckmorton, Amy L.;Ballman, Kimberly K.;Rodefeld, Mark D.
目的。我们假设螺旋桨泵设计将在单室Fontan循环中提供腔肺辅助功能。对刚性三叶螺旋桨样机(类似于折叠式螺旋桨设计)的水力和溶血性能进行了表征。压力和流量测量采用血液模拟液，流速为0.5至3升/分钟(LPM)，转速为5,000至7,000转/分钟(RPM)。用新鲜牛血在6000转/分的条件下进行2升/分的溶血试验，持续6小时。样机表现良好，超过了设计工作范围，产生了5至50毫米汞柱的压力上升。血浆游离血红蛋白浓度维持在15 mg/dL以下。溶血归一化指数在1h内达到峰值，此后维持在10 mg/dL以下。螺旋桨泵具有压力-流量特性，溶血和静脉通路阻塞的风险最小，这使其成为临时性腔肺辅助的理想选择。这种类型的装置有可能为单室Fontan生理学衰竭的患者提供一种新的治疗选择，作为通往康复或移植的桥梁。
Purpose. We hypothesized that a propeller pump design would function optimally to provide cavopulmonary assist in a univentricular Fontan circulation.Description. The hydraulic and hemolysis performance of a rigid three-bladed propeller prototype (similar to a folding propeller design) was characterized. Pressure and flow measurements were taken for flow rates of 0.5 to 3 liters per minute (LPM) for 5,000 to 7,000 revolutions per minute (RPM) using a blood analog fluid. Hemolysis testing was performed using fresh bovine blood for 2 LPM at 6,000 RPM for a 6-hour duration.Evaluation. The prototype performed well over the design operating range by producing a pressure rise of 5 to 50 mm Hg. Plasma free hemoglobin concentration remained less than 15 mg/dL. The normalized index of hemolysis peaked during the first hour, and then remained less than 10 mg/dL thereafter.Conclusions. A propeller pump has the pressure-flow characteristics and minimal risk of hemolysis and venous pathway obstruction which make it ideal for temporary cavopulmonary assist. This type of device has the potential to provide a new therapeutic option for patients with failing univentricular Fontan physiology as a bridge-to-recovery or transplantation.