Macrophages and the Recovery from Acute and Chronic Inflammation.
Macrophages and the Recovery from Acute and Chronic Inflammation.
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DOI：
10.1146/annurev-physiol-022516-034348
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发表时间：
2017-02-10
影响因子：
18.2
通讯作者：
Mosser DM
中科院分区：
文献类型：
--
作者：
Hamidzadeh K;Christensen SM;Dalby E;Chandrasekaran P;Mosser DM
近年来，研究人员对巨噬细胞的多种作用及其对组织发育、伤口愈合和血管生成的贡献给予了极大关注。在关于这些细胞的多样性生物学的讨论中不应该丢失的是，当受到干扰时，巨噬细胞是潜在病理性炎症过程的主要贡献者。巨噬细胞随时准备迅速产生大量的炎症细胞因子，以应对危险信号。这些细胞因子的产生可以启动炎症介质释放的级联反应，其可以导致大规模组织破坏。巨噬细胞的破坏性炎症能力通过暴露于外源性干扰素-γ而被放大，这增强并加剧了炎症反应。简单地说，巨噬细胞可以被看作是一种等待引爆的燃烧装置。我们已经开始询问如何调节这些细胞以减轻与巨噬细胞活化相关的附带破坏。
In recent years, researchers have devoted much attention to the diverse roles of macrophages and their contributions to tissue development, wound healing, and angiogenesis. What should not be lost in the discussions regarding the diverse biology of these cells is that when perturbed, macrophages are the primary contributors to potentially pathological inflammatory processes. Macrophages stand poised to rapidly produce large amounts of inflammatory cytokines in response to danger signals. The production of these cytokines can initiate a cascade of inflammatory mediator release that can lead to wholesale tissue destruction. The destructive inflammatory capability of macrophages is amplified by exposure to exogenous interferon-γ, which prolongs and heightens inflammatory responses. In simple terms, macrophages can thus be viewed as incendiary devices with hair triggers waiting to detonate. We have begun to ask questions about how these cells can be regulated to mitigate the collateral destruction associated with macrophage activation.
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对代谢触发的炎症的负调节反应会损害糖尿病中的肾上皮免疫。
影响因子：
4.7
作者：
Chen, Nelson K. F.;Chong, Tsung Wen;Loh, Hwai-Liang;Lim, Kiat Hon;Gan, Valerie H. L.;Wang, Marian;Kon, Oi Lian
通讯作者：
Kon, Oi Lian
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作者：
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通讯作者：
Saha B
影响因子：
4.4
作者：
Bergeron, Marc;Olivier, Martin
通讯作者：
Olivier, Martin
影响因子：
6.2
作者：
Caso F;Galozzi P;Costa L;Sfriso P;Cantarini L;Punzi L
通讯作者：
Punzi L
影响因子：
30.5
作者：
Boone, DL;Turer, EE;Ma, A
通讯作者：
Ma, A