Systems Toxicology
Systems Toxicology
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DOI：
10.14573/altex.2012.2.119
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发表时间：
2012-01-01
影响因子：
5.6
通讯作者：
Thomas, Russell
中科院分区：
文献类型：
--
作者：
Hartung, Thomas;van Vliet, Erwin;Thomas, Russell
如果我们要确定和更好地评估与制药、化学、农业生物和化妆品行业开发的各种物质有关的安全问题，那么迫切需要对化学品调节生物途径的方式进行更机械的理解。百合花技术提供了宝贵的机会，可以改进现有方法，并通过创建毒性特征为所谓的综合测试战略提供信息。通过将这些特征映射到潜在的毒性途径，其中一些已被毒理学家在过去几十年中确定，并将它们与从生物化学和分子生物学确定的途径信息结合在一起，“系统毒理学”方法将使虚拟实验能够进行，从而改善对危害的预测和对化合物毒性的评估。
The need for a more mechanistic understanding of the ways in which chemicals modulate biological pathways is urgent if we are to identify and better assess safety issues relating to a wide range of substances developed by the pharmaceutical, chemical, agri-bio, and cosmetic industries. lilies technologies provide valuable opportunity to refine existing methods and provide information for so-called integrated testing strategies via the creation of signatures of toxicity. By mapping these signatures to underlying pathways of toxicity, some of which have been identified by toxicologists over the last few decades, and bringing them together with pathway information determined from biochemistry and molecular biology, a "systems toxicology" approach will enable virtual experiments to be conducted that can improve the prediction of hazard and the assessment of compound toxicity.