Insights from nanotechnology in COVID-19 treatment.

Insights from nanotechnology in COVID-19 treatment.
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纳米技术在COVID-19治疗中的见解。

DOI:
10.1016/j.nantod.2020.101019
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发表时间:
2021-03
期刊:
影响因子:
17.4
通讯作者:
Tao W
Tao W
中科院分区:
材料科学1区
文献类型:
--
作者:
Tang Z;Zhang X;Shu Y;Guo M;Zhang H;Tao W

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在短短几个月内,SARS-CoV-2及其引起的疾病COVID-19造成了全球大流行。病毒学家、生物学家、药剂师、材料科学家和临床医生正在合作开发有效的治疗策略。总体而言,除了使用临床设备协助患者康复外,抗病毒药物和疫苗是最受关注的领域。考虑到SARS-CoV-2的物理尺寸和目前正在临床试验中的疫苗输送平台,纳米技术的相关性是显而易见的,以前使用纳米材料的抗病毒研究也支持这种联系。本文简要总结了纳米材料在抗病毒研究中的代表性策略。我们特别关注SARS-CoV-2和纳米技术在应对这一大流行病中可以发挥的详细作用,包括i)使用FDA批准的纳米材料进行药物/疫苗递送,包括进一步探索吸入途径; ii)引入目前正在临床试验中的有前途的纳米材料用于药物/疫苗递送; iii)设计新型生物相容性纳米材料,通过干扰其生命周期来对抗病毒;以及iv)促进纳米材料在肺炎治疗中的应用。
In just a few months, SARS-CoV-2 and the disease it causes, COVID-19, created a worldwide pandemic. Virologists, biologists, pharmacists, materials scientists, and clinicians are collaborating to develop efficient treatment strategies. Overall, in addition to the use of clinical equipment to assist patient rehabilitation, antiviral drugs and vaccines are the areas of greatest focus. Given the physical size of SARS-CoV-2 and the vaccine delivery platforms currently in clinical trials, the relevance of nanotechnology is clear, and previous antiviral research using nanomaterials also supports this connection. Herein we briefly summarize current representative strategies regarding nanomaterials in antiviral research. We focus specifically on SARS-CoV-2 and the detailed role that nanotechnology can play in addressing this pandemic, including i) using FDA-approved nanomaterials for drug/vaccine delivery, including further exploration of the inhalation pathway; ii) introducing promising nanomaterials currently in clinical trials for drug/vaccine delivery; iii) designing novel biocompatible nanomaterials to combat the virus via interfering in its life cycle; and iv) promoting the utilization of nanomaterials in pneumonia treatment.
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