GABAERGIC AGENTS IN THE MEDIAL SEPTAL NUCLEUS AFFECT HIPPOCAMPAL THETA-RHYTHM AND ACETYLCHOLINE UTILIZATION
GABAERGIC AGENTS IN THE MEDIAL SEPTAL NUCLEUS AFFECT HIPPOCAMPAL THETA-RHYTHM AND ACETYLCHOLINE UTILIZATION
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DOI：
10.1016/0006-8993(84)90116-1
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发表时间：
1984-01-01
期刊：
影响因子：
2.9
通讯作者：
CRAWFORD, IL
中科院分区：
文献类型：
--
作者：
ALLEN, CN;CRAWFORD, IL
内侧隔核的神经元在调节海马体的生理活动中起着重要作用。如果间隔内注射假定的神经递质物质影响海马乙酰胆碱[ACh]的周转率，那么预计海马区的电生理活动也会随之改变。将GABA激动剂麝香酚注入大鼠内侧隔区，观察其对海马电活动和ACh利用率的影响。隔内注射蝇草醇(100 Ng)后，与对照组注射生理盐水相比，海马区记录到的低幅度非同步波和节律性慢活动(RSA，6-9赫兹)显著减少。这种作用可被预先间隔内注射荷包牡丹碱(3微克)所拮抗。海马电活动在100min内恢复正常。在给药后，间隔内注射蝇草酚可显着降低ACh的利用率，同时也改变了脑电活动，增加了自发行为活动。显然，在海马RSA的产生和隔区的GABA能机制之间存在生理联系。
Neurons of the medial septal nucleus are important in regulating the physiological activity of the hippocampus. If intraseptal injection of putative neurotransmitter substances affects the turnover rate of hippocampal acetylcholine [ACh], then concomitant changes would be expected in the electrophysiologic activity of the hippocampus. A GABA agonist, muscimol, was injected into the medial septum of rats and the effects on hippocampal electrical activity and ACh utilization were studied. The intraseptally injected muscimol (100 ng) resulted in hippocampal electrographic records containing low amplitude asynchronous waves and significantly less rhythmic slow activity (RSA, 6-9 Hz), compared to control injections of saline. This effect was antagonized by prior intraseptal injection of bicuculline (3 .mu.g). The hippocampal electrical activity returned to normal within 100 min. The utilization of ACh was significantly reduced by intraseptal muscimol at times after administration when electrographic activity was also altered and spontaneous behavioral movement was increased. Evidently, there is a physiological connection between hippocampal RSA generation and GABAergic mechanisms in the septum.