Reliability, validity, and clinical correlates of apathy in Parkinson's disease.
Reliability, validity, and clinical correlates of apathy in Parkinson's disease.
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DOI：
10.1176/jnp.4.2.134
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
S. Starkstein;H. Mayberg;T. Preziosi;P. Andrezejewski;R. Leiguarda;R. Robinson
中科院分区：
文献类型：
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作者：
S. Starkstein;H. Mayberg;T. Preziosi;P. Andrezejewski;R. Leiguarda;R. Robinson
作者使用包括最近设计的冷漠量表在内的神经心理学成套工具，检查了50例患者的冷漠、抑郁、焦虑和神经心理学缺陷。该量表被认为是可靠的和有效的PD患者的冷漠的诊断。在这项研究中，12%的患者表现出冷漠是他们的主要精神问题，30%的患者既冷漠又抑郁。冷漠患者（伴或不伴抑郁）在言语记忆和时间依赖性任务中表现出明显更多的缺陷。结果表明，冷漠是PD的常见发现，与特定的认知障碍显着相关，并且可能具有与抑郁症不同的机制。
The authors examined a consecutive series of 50 patients for the presence of apathy, depression, anxiety, and neuropsychological deficits using a neuropsychological battery that included a recently designed apathy scale. This scale was found to be reliable and valid in the diagnosis of apathy in patients with PD. Of patients in the study, 12% showed apathy as their primary psychiatric problem, and 30% were both apathetic and depressed. Patients with apathy (with or without depression), showed significantly more deficits in both tasks of verbal memory and time-dependent tasks. Results suggest that apathy is a frequent finding in PD, is significantly associated with specific cognitive impairments, and may have a different mechanism than depression.