Dynamics and thermodynamics of dimerization of parallel G-quadruplexed DNA formed from d(TTAGn) (n=3-5)
Dynamics and thermodynamics of dimerization of parallel G-quadruplexed DNA formed from d(TTAGn) (n=3-5)
复制标题
DOI：
10.1021/ja050191b
复制
发表时间：
2005-07-20
影响因子：
15
通讯作者：
Yamamoto, Y
中科院分区：
文献类型：
--
作者：
Kato, Y;Ohyama, T;Yamamoto, Y
由寡核苷酸序列d（TTAGn）（其中n = 3−5）形成的平行G-四链体已被证明通过3 '-末端G-四联体的端对端堆叠形成二聚体。G-四链体的单体和二聚体处于动态平衡，交换速率为0.1s-1。热力学研究表明，G-四链体的二聚化在很大程度上是同源的。
Parallel G-quadruplexes formed from oligonucleotide sequences, d(TTAGn), wheren= 3−5, have been shown to form a dimer through end-to-end stacking of 3‘-terminal G-tetrads. The monomers and dimers of the G-quadruplexes are in dynamic equilibrium with an exchange rate of ∼1 s-1. A thermodynamic study demonstrated that the dimerization of the G-quadruplexes is largely enthalpic in origin.