Factors associated with positive outcomes of platelet-rich plasma therapy in Achilles tendinopathy
Factors associated with positive outcomes of platelet-rich plasma therapy in Achilles tendinopathy
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DOI：
10.1007/s00590-020-02642-1
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发表时间：
2020-07-01
影响因子：
1.7
通讯作者：
Salini, Vincenzo
中科院分区：
文献类型：
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作者：
Abate, Michele;Di Carlo, Luigi;Salini, Vincenzo
背景富血小板血浆治疗跟腱病的疗效存在争议。因此，了解与受试者和/或疾病相关的哪些因素与阳性或阴性结局相关非常重要。本研究的目的是评估在一个大的队列的患者跟腱中段肌腱病变的变量独立相关的一个积极的结果后，血小板丰富的plasma treatment.Material和methodsEighty-four与跟腱病变的受试者进行了评估，通过VISA-A评分和超声和治疗与一个单一的血小板丰富的血浆注射每周一次，为期3周。之后，实施了一项基于偏心训练的康复计划。在3个月和6个月时，评估平均VISA-A评分与以下假定预测因素之间的关系：性别、年龄、体力活动、运动、吸烟、代谢危险因素、BMI、症状持续时间、肌腱损伤、新生血管、坚持离心训练。最后，计算与每个变量相关的临床明显阳性结果（定义为VISA-A评分增加>= 20分）的百分比。
BackgroundThe efficacy of platelet-rich plasma in the treatment for Achilles tendinopathy is debated. Therefore, it is important to know which factors, related to the subjects and/or the disease, are associated with positive or negative outcomes. Aim of this study was to evaluate in a large cohort of patients with Achilles mid-portion tendinopathy which variables were independently associated with a positive outcome after platelet-rich plasma treatment.Material and methodsEighty-four subjects with Achilles tendinopathy were evaluated by means of VISA-A score and ultrasound and treated with a single platelet-rich plasma injection once a week for 3 weeks. Afterward, a rehabilitation program, based on eccentric training, was implemented. At 3 and 6 months, the relationship between the mean VISA-A score and the following putative predictors was evaluated: sex, age, physical activity, sport, smoking, metabolic risk factors, BMI, symptoms duration, tendon damage, neovessels, adherence to eccentric training. Finally, the percentage of clinically evident positive outcomes (defined as an increase in VISA-A score >= 20 points) related to each variable was computed.ResultsAt final follow-up, using the General Linear Model for Repeated Measures procedure, male sex (0.02), age