Long non-coding RNA ZEB1-AS1 promotes colon adenocarcinoma malignant progression via miR-455-3p/PAK2 axis.
Long non-coding RNA ZEB1-AS1 promotes colon adenocarcinoma malignant progression via miR-455-3p/PAK2 axis.
复制标题
长非编码RNA ZEB1-AS1通过miR-455-3p/PAK2轴促进结肠腺癌恶性进展。
DOI：
10.1002/jmv.25654
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发表时间：
2020
影响因子：
8.5
通讯作者：
Xu Min
中科院分区：
文献类型：
--
作者：
Ni Xin;Ding Yu-Ting;Yuan Hai-Tao;Shao Jin-Min;Yan Yan;Guo Rou-Yu;Luan Wen-Kang;Xu Min
虽然寨卡病毒（ZIKV）感染主要通过蚊虫叮咬传播，但它也可以通过输血传播。2015年至2016年，美洲报告了50多万例寨卡病毒感染病例。截至目前，由于国际交流频繁，中国广东省深圳市共报告输入性寨卡病毒感染病例10余例。不幸的是，没有关于中国献血者中寨卡病毒感染的数据，因为它没有被纳入志愿献血者的常规筛查。因此，我们对中国深圳志愿献血者中寨卡病毒感染流行率进行了初步调查，以评估通过输血感染寨卡病毒的潜在风险。采集9626份献血者血样，采用转录介导扩增（TMA）核酸扩增法，采用西班牙Grifols公司Panther核酸自动分析系统（含Procleix ZIKV检测试剂）检测寨卡病毒RNA。本研究所有实验均按照血液中心的标准操作程序进行。在9626份供者血液样本中，这些样本都没有寨卡病毒RNA反应。初步调查未发现寨卡病毒RNA筛选阳性病例。初步调查显示，中国深圳献血者中未发现寨卡病毒。目前深圳输血感染寨卡病毒的潜在风险较低。因此，没有必要将寨卡病毒核酸检测作为献血者的常规筛查。
Although Zika virus (ZIKV) infection is mainly transmitted through mosquito bite, it can also be transmitted through blood transfusion. More than 500 000 cases of ZIKV infection were reported in the Americas from 2015 to 2016. Up till now, over 10 cases of imported ZIKV infection have been reported due to frequent international exchanges in the Shenzhen city of Guangdong Province, China. Unfortunately, there were no data on ZIKV infection in Chinese blood donors because it has not been included in routine screening for volunteer blood donors. As such, we performed a preliminary survey of the prevalence of ZIKV infection among volunteer blood donors in Shenzhen, China, to assess the potential risk of ZIKV infection through transfusion. A total of 9626 blood donor samples were collected and ZIKA RNA was detected by transcription‐mediated amplification (TMA) nucleic acid amplification method with the Panther nucleic acid automatic analysis system of Grifols, Spain, including Procleix ZIKV Assay reagent. All the experiments in this study were conducted in accordance with the standard operating procedure of the blood center. Of the 9626 donor blood samples tested, none of these samples was Zika RNA reactive. There was no positive case from ZIKV RNA screening in this preliminary survey. There was no ZIKV presence in blood donors in Shenzhen, China, from this preliminary survey. The potential risk of ZIKV infection by transfusion is low in Shenzhen at this moment. Therefore, there is no need to add ZIKV nucleic acid test as a routine screening for blood donors.