Exercise training reduces ischemic myocardial dysfunction.
Exercise training reduces ischemic myocardial dysfunction.
复制标题
运动训练可减少缺血性心肌功能障碍。
DOI：
10.1097/00005768-200104000-00008
复制
发表时间：
2001
影响因子：
4.1
通讯作者：
Gwirtz,PA
中科院分区：
文献类型：
--
作者：
Brandt,MA;Gwirtz,PA
本研究验证了运动训练改善冠脉闭塞时邻近缺血区的侧缘区心肌血流量和局部心肌收缩功能的假说。犬麻醉后用仪器测量中心缺血区、侧缘缺血区和非缺血区的局部心肌收缩功能(节段长度缩短百分比和缩短率)和局部心肌血流量(示踪微球)。分别于结扎前、结扎左冠状动脉前降支(CAO)后2min和3h进行测量。结果无论是笼养犬还是运动训练犬，CAO对非缺血区的收缩功能和局部心肌血流量均无明显影响。在CAO后2min和3h，运动训练犬心肌局部收缩功能和侧缘区血流量均显著高于笼养犬。在CAO后2分钟和3小时，笼养犬和运动训练犬的中央缺血区的缺血功能障碍相似。在CAO后2分钟，两组缺血区心肌局部血流量相似，但在运动训练心脏内膜下3h后，缺血区心肌血流量显著增加(P<；0.05)。结论运动训练动物CAO持续时间延长，心肌边缘区血流灌注增加，与心肌收缩功能显著改善有关。
PurposeThis study tested the hypothesis that exercise training improves myocardial blood flow and regional myocardial contractile function in a lateral border zone located adjacent to the ischemic zone during coronary artery occlusion.MethodsFourteen dogs were subjected to either 12 wk of dynamic exercise training or cage rest. Dogs were anesthetized and instrumented to assess regional myocardial contractile function (percent segment length shortening and rate of shortening) and regional myocardial blood flow (tracer microspheres) in the central ischemic, lateral border, and nonischemic zones. Measurements were made preocclusion and at 2 min and 3 h after occlusion of the left anterior descending coronary artery (CAO).ResultsContractile function and regional myocardial blood flow were not affected by CAO in the nonischemic zone in both cage-rested and exercise trained dogs. Regional myocardial contractile function and blood flow in the lateral border zone were significantly higher in exercise trained dogs compared with cage-rested dogs, both at 2 min and 3 h after CAO. Ischemic dysfunction was similar in the central ischemic zone in both cage-rested and exercise trained dogs both at 2 min and 3 h after CAO. Regional myocardial blood flow was similarly reduced in the ischemic zone in both groups after 2 min of CAO, but was significantly higher in the inner (subendocardial) region of the exercised trained hearts after 3 h (P< 0.05).ConclusionThese data suggest that there was greater border zone perfusion in exercise trained animals during prolonged CAO, which was associated with significantly improved myocardial contractile function.