Modifications of poly(o-phenylenediamine) permselective layer on Pt-Ir for biosensor application in neurochemical monitoring
Modifications of poly(o-phenylenediamine) permselective layer on Pt-Ir for biosensor application in neurochemical monitoring
复制标题
DOI：
10.3390/s7040420
复制
发表时间：
2007-04-01
期刊：
影响因子：
3.9
通讯作者：
O'Neill, Robert D.
中科院分区：
文献类型：
--
作者：
Kirwan, Sarah M.;Rocchitta, Gaia;O'Neill, Robert D.
球形蛋白可以增强PPD（聚邻苯二胺）层的干扰阻断能力的报道在生物传感器设计中用作选择性渗透屏障，促使本研究在PPD在Pt-Ir电极上的电合成期间将各种修饰剂并入PPD。被困的分子，包括纤维蛋白质和β-环糊精，改变了聚合物/改性剂复合材料的选择性，通过影响的敏感性H2 O2（信号分子在许多酶为基础的生物传感器）和原型的干扰物种，抗坏血酸。Pt和Pt-Ir合金的电化学性质的比较表明，后者的好处，更刚性，金属可以利用在PPD为基础的生物传感器设计没有显着损失的向后兼容性与纯Pt的研究。
Reports that globular proteins could enhance the interference blocking ability of the PPD (poly(o-phenylenediamine) layer used as a permselective barrier in biosensor design, prompted this study where a variety of modifying agents were incorporated into PPD during its electrosynthesis on Pt-Ir electrodes. Trapped molecules, including fibrous proteins and beta-cyclodextrin, altered the polymer/modifier composite selectivity by affecting the sensitivity to both H2O2 (signal molecule in many enzyme-based biosensors) and the archetypal interference species, ascorbic acid. A comparison of electrochemical properties of Pt and a Pt-Ir alloy suggests that the benefits of the latter, more rigid, metal can be exploited in PPD-based biosensor design without significant loss of backward compatibility with studies involving pure Pt.