Mapping cortical thickness and gray matter concentration in first episode schizophrenia
Mapping cortical thickness and gray matter concentration in first episode schizophrenia
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DOI：
10.1093/cercor/bhh172
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发表时间：
2005-06-01
期刊：
影响因子：
3.7
通讯作者：
Thompson, PM
中科院分区：
文献类型：
--
作者：
Narr, KL;Bilder, RM;Thompson, PM
我们绘制了首发精神分裂症患者皮层厚度和基于强度的皮层灰质浓度的区域变化。对72例首发患者（男51例，女21例）和78例年龄相近的健康受试者（男37例，女41例）进行高分辨率磁共振成像。皮质模式匹配方法可以在三维空间上比较受试者之间数千个同源皮质位置的皮质厚度和灰质浓度。主成分分析减少了整个皮层的测量，以确定皮层厚度/灰质浓度的整体差异。第一主成分因子得分显示诊断、性别和年龄对两种皮质测量有显著影响。脑尺寸校正后，诊断和年龄影响仍然显著。皮层厚度与灰质浓度值高度相关。统计图显示首发患者双侧额叶、颞叶和顶叶异型联合皮层的区域灰质明显变薄。皮层灰质浓度的区域性减少与此相似，但在颞叶上明显。与精神分裂症功能障碍相关的脑区发病时出现皮质厚度和灰质浓度的区域性减少。尽管浓度度量可能受到皮质外脑脊液和表面曲率/复杂性的诊断差异的影响，但皮质厚度和灰质浓度制图产生相似的结果。
We mapped regional changes in cortical thickness and intensity-based cortical gray matter concentration in first episode schizophrenia. High-resolution magnetic resonance images were obtained from 72 (51 male, 21 female) first episode patients and 78 (37 male, 41 female) healthy subjects similar in age. Cortical pattern matching methods allowed comparisons of cortical thickness and gray matter concentration at thousands of homologous cortical locations between subjects in three dimensions. Principal components analyses reduced measures obtained across the cortex to identify global differences in cortical thickness/gray matter concentration. First principal component factor scores showed significant effects of diagnosis, sex and age for both cortical measures. Diagnosis and age effects remained significant after brain size correction. Cortical thickness and gray matter concentration values were highly correlated. Statistical maps showed significant regional gray matter thinning in frontal, temporal and parietal heteromodal association cortices bilaterally in first episode patients. Regional reductions in cortical gray matter concentration were similar but pronounced in the superior temporal lobe. Regional reductions in cortical thickness and gray matter concentration are present at disease onset in brain regions linked with functional disturbances in schizophrenia. Cortical thickness and gray matter concentration mapping produce similar results, although the concentration metric may be influenced by diagnostic differences in extra-cortical cerebrospinal fluid and surface curvature/complexity.