New Insights into the Role of E2s in the Pathogenesis of Diseases: Lessons Learned from UBE2O.
New Insights into the Role of E2s in the Pathogenesis of Diseases: Lessons Learned from UBE2O.
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DOI：
10.14348/molcells.2018.0008
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发表时间：
2018-03-31
影响因子：
3.8
通讯作者：
Song SJ
中科院分区：
文献类型：
--
作者：
Hormaechea-Agulla D;Kim Y;Song MS;Song SJ
通过泛素（Ub）信号传导的细胞内通信影响细胞生物学的各个方面，并调节对人类发育和生存能力至关重要的途径；因此，Ub信号的畸变或缺陷可能与人类疾病的发病机制有关。泛素化是通过e1激活酶、e2偶联酶和e3连接酶的协同作用将Ub添加到底物蛋白上。在人类中发现了大约40个E2s，大多数被认为与Ub转移有关；虽然关于其中大多数的信息很少，但新出现的证据突出了它们对人类健康和疾病的重要性。在这篇综述中，我们重点介绍了E2s（特别是泛素偶联酶E2O [UBE2O]）在衰弱性疾病和癌症中的致病作用，并讨论了E2s可能有朝一日成为人类疾病的潜在治疗靶点的诱人前景。
Intracellular communication via ubiquitin (Ub) signaling impacts all aspects of cell biology and regulates pathways critical to human development and viability; therefore aberrations or defects in Ub signaling can contribute to the pathogenesis of human diseases. Ubiquitination consists of the addition of Ub to a substrate protein via coordinated action of E1-activating, E2-conjugating and E3-ligating enzymes. Approximately 40 E2s have been identified in humans, and most are thought to be involved in Ub transfer; although little information is available regarding the majority of them, emerging evidence has highlighted their importance to human health and disease. In this review, we focus on recent insights into the pathogenetic roles of E2s (particularly the ubiquitin-conjugating enzyme E2O [UBE2O]) in debilitating diseases and cancer, and discuss the tantalizing prospect that E2s may someday serve as potential therapeutic targets for human diseases.