The Neural Correlates of Planning and Executing Actual Tool Use
The Neural Correlates of Planning and Executing Actual Tool Use
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DOI：
10.1523/jneurosci.0597-14.2014
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发表时间：
2014-09-24
影响因子：
5.3
通讯作者：
Hermsdoerfer, Joachim
中科院分区：
文献类型：
--
作者：
Brandi, Marie-Luise;Wohlschlaeger, Afra;Hermsdoerfer, Joachim
人类工具的使用是复杂的，潜在的神经机制似乎广泛分布在几个大脑系统中，然而，实际工具使用的神经影像学研究是罕见的，因为实验的挑战阻碍了详细的分析在一个代理主题。我们开发了一个“工具卡”，使我们能够在功能磁共振成像过程中测试不同物体的实际操作，并调查目标导向行动的计划和执行。特别是，我们专注于三个因素对物体操作的影响：操作的对象类型，操作的类型，和要使用的手。主要的焦点在于如何复杂的对象使用相比，非特定的行动是处理的问题，特别是如何这样的表示与知识的对象在行动相关的背流。我们发现，用右手和左手进行物体操作时，会招募一个共同的网络，该网络强烈偏向左半球，特别是在计划和动作执行期间。具体来说，虽然腹侧流的活动涉及处理语义信息和对象属性，但背-背通路（即，上级枕回、上级顶叶小叶和背侧运动前区）与监测对象的在线控制以及腹-背路径（即，枕中回、顶下小叶和腹侧运动前区）具体参与处理已知的物体操作，例如工具使用。数据进一步表明腹侧流区，如颞中回和枕外侧复合体，与两个背侧通路的相互作用。这些结果提供了证据，左侧枕颞顶额网络的日常工具使用，这可能有助于表征特定的缺陷，患有失用症。
Human tool use is complex, and underlying neural mechanisms seem to be widely distributed across several brain systems; however, neuroimaging studies of actual tool use are rare because of experimental challenges hindering detailed analysis within one acting subject. Wedeveloped a "Tool-Carousel" that enabled us to test actual manipulation of different objects during fMRI and investigate the planning and execution of goal-directed actions. Particularly, we focused on the effects of three factors on object manipulations: the type of object manipulated, the type of manipulation, and the hand to be used. The main focus lay on the question of how complex object use compared with unspecific actions are processed and especially how such representations interact with the knowledge about the object in the action-related dorsal stream. We found that object manipulations with both right and left hand recruit a common network strongly lateralized to the left hemisphere especially during planning but also action execution. Specifically, while activity in the ventral stream was involved in processing semantic information and object properties, a dorso-dorsal pathway (i.e., superior occipital gyrus, superior parietal lobule, and dorsal premotor area) was relevant for monitoring the online control of objects and also a ventro-dorsal pathway (i.e., middle occipital gyrus, inferior parietal lobule, and ventral premotor area) was specifically involved in processing known object manipulations, such as tool use. Data further indicate an interaction of ventral stream areas, such as middle temporal gyrus and lateral occipital complex, with both dorsal pathways. These results provide evidence for left-lateralized occipito-temporo-parieto-frontal network of everyday tool use, which may help to characterize specific deficits in patients suffering from apraxia.