NF00659A1, A2, A3, B1, and B2 Novel Antitumor Antibiotics Produced by Aspergillus sp. NF 00659. Part 2. Structural Elucidation.
NF00659A1, A2, A3, B1, and B2 Novel Antitumor Antibiotics Produced by Aspergillus sp. NF 00659. Part 2. Structural Elucidation.
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DOI：
10.1002/chin.199742282
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发表时间：
1997-10
期刊：
影响因子：
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通讯作者：
Katsuhiro Suzuki;A. Kuwahara;T. Nishikiori;T. Nakagawa
中科院分区：
文献类型：
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作者：
Katsuhiro Suzuki;A. Kuwahara;T. Nishikiori;T. Nakagawa
NF 00659 Ax（1）、A2（2）、B±（4）和B2（5）分离为白色粉末，A3（3）为无色晶体。NF 00659的理化性质总结见表1。用FAB-MS在正离子和负离子模式下获得NF 00659的分子量。在正离子模式中，1、2和3给出脱水离子峰[M-OH]+，而4和5没有给出脱水离子峰。化合物1和4在265 nm处有较强的紫外吸收，化合物2和5在300 nm处有较强的紫外吸收。化合物1、2、4和5的红外光谱表明存在不饱和酯（1710~ 1706
NF00659Ax (1), A2 (2), B±(4) and B2 (5) were isolated as white powders and A3 (3) was as colorless crystals. Thephysico-chemical properties of NF00659sare summarized in Table 1. The molecular weights of NF00659s were obtained with FAB-MSin the positive and negative ion modes. In the positive ion mode, 1, 2 and 3 gave a dehydrated ion peak [M-OH]+ while 4 and 5 gave no dehydrated ion peak. Thestrong UVabsorption was observed at 265nm (s 28,000) for 1 and 4, and at 300nm (e 44,000) for 2 and 5. The IR spectra of1, 2, 4 and 5 suggested the presence of unsaturated ester (1710~ 1706