Direct access to substituted benzo[b]carbazoles through cascade annulation of 2-vinylbenzaldehydes with indoles
Direct access to substituted benzo[b]carbazoles through cascade annulation of 2-vinylbenzaldehydes with indoles
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通过 2-乙烯基苯甲醛与吲哚的级联环化直接获得取代的苯并[b]咔唑
DOI：
10.1039/c8cc10253h
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发表时间：
2019
影响因子：
4.9
通讯作者：
Liu Pei-Nian
中科院分区：
文献类型：
--
作者：
Li Deng-Yuan;Wang An;Zhu Xiao-Ping;Feng Wei;Liu Pei-Nian
在钯的催化下，2-乙烯基苯甲醛与吲哚的级联环化反应获得了6-(3-吲哚)苯并[b]咔唑，反应条件温和，产率高，区域选择性好。机理研究表明，该反应通过吲哚双加成、分子内意外的1，4-芳基和1，2-氢迁移以及氧化芳构化进行。
A highly efficient palladium-catalyzed cascade annulation of 2-vinylbenzaldehydes with indoles has been achieved to afford 6-(3-indolyl)benzo[b]carbazoles under mild conditions in good yield and with excellent regioselectivity. Mechanistic investigations reveal that the reaction proceeds via double addition of indoles, unexpected intramolecular 1,4-aryl and 1,2-hydrogen migrations, and oxidative aromatization.