Seroprevalence of Chikungunya virus (CHIKV) infection on Lamu Island, Kenya, October
Seroprevalence of Chikungunya virus (CHIKV) infection on Lamu Island, Kenya, October
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DOI：
10.4269/ajtmh.2008.78.333
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发表时间：
2008-02-01
影响因子：
3.3
通讯作者：
Breiman, Robert F.
中科院分区：
文献类型：
--
作者：
Sergon, Kibet;Njuguna, Charles;Breiman, Robert F.
在肯尼亚拉穆发现了与高烧和严重慢性关节痛相关的基孔肯雅病毒（CHIKV）病暴发，并于2004年7月达到高峰。记录在案的病例至少有1300例。我们进行了一项血清流行率研究，以确定拉穆岛的传播程度。我们进行了一次系统的横断面调查。我们对288份拉穆居民的血清进行了调查问卷和IgG抗体检测。基孔肯雅病毒感染（血清阳性）定义为具有基孔肯雅病毒IgG和/或IgM抗体的人。18%（53/288）和72%（206/288）分别检测到IgM抗体和IgG抗体；75%（215/288）存在IgM和/或IgG抗体。检疫率调查结果表明，疫情是广泛的，影响了75%的拉穆人；将研究结果外推到整个人群，有13,500人（95% CI, 12,45814328）受到影响。需要采取媒介控制战略来控制这种蚊媒感染的传播。
An outbreak of Chikungunya virus (CHIKV) disease associated with high fever and severe protracted arthralgias was detected in Lamu, Kenya, peaking in July 2004. At least 1,300 cases were documented. We conducted a seroprevalence study to define the magnitude of transmission on Lamu Island. We conducted a systematic cross-sectional survey. We administered questionnaires and tested 288 sera from Lamu residents for IgM and IgG antibodies to CHIKV. Chikungunya virus infection (seropositivity) was defined as a person with IgG and/or IgM antibodies to CHIKV. IgM antibodies to CHIKV were detected in 18% (53/288) and IgG antibodies in 72% (206/288); IgM and/or IgG antibodies were present in 75% (215/288). The scroprevalence findings suggested that the outbreak was widespread, affecting 75% of the Lamu population; extrapolating the findings to the entire population, 13,500 (95% CI, 12,45814328) were affected. Vector control strategies are needed to control the spread of this mosquito-borne infection.