Distinct behavioural profiles in frontotemporal dementia and semantic dementia
Distinct behavioural profiles in frontotemporal dementia and semantic dementia
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DOI：
10.1136/jnnp.70.3.323
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发表时间：
2001-03-01
影响因子：
11
通讯作者：
Neary, D
中科院分区：
文献类型：
--
作者：
Snowden, JS;Bathgate, D;Neary, D
额颞叶痴呆和语义性痴呆引起不同的行为变化模式的预测进行测试。方法基于信息者的半结构化行为访谈，涵盖基本和社会情感，社会和个人行为，感官行为，饮食和口腔行为，重复行为，仪式和强迫，管理41例语义性痴呆和冷漠（FTD-A）和去抑制（FTD-D）形式的额颞叶dementials.Results-Consistent预测，情感变化区分FTD从语义性痴呆的照顾者。虽然缺乏情绪反应是普遍的FTD，它是更有选择性的语义痴呆，特别是影响能力，以显示恐惧。社交回避在FTD中更常见，社交寻求在语义性痴呆中更常见。FTD患者表现出对疼痛的反应降低，而语义性痴呆患者更常表现出对感觉刺激的夸大反应。暴食和乱吃是FTD的特征，而语义性痴呆患者更可能表现出食物时尚。涉及不可食用物体的过度口腔行为与暴食无关，表明不同的潜在机制。重复行为在FTD和语义性痴呆中很常见，但在语义性痴呆中具有更强的强迫性。语义性痴呆和FTD-A之间的行为差异大于FTD-D。Logistic回归分析表明，情感和重复，强迫行为的歧视FTD语义dementia与97%的accuracy. Conclusion-研究结果证实预测额颞叶和语义dementia的行为差异，并指出不同的作用，额叶和颞叶的影响，社会功能，饮食和强迫行为。
Objective-To test predictions that frontotemporal dementia and semantic dementia give rise to distinct patterns of behavioural change.Methods-An informant based semistructured behavioural interview, covering the domains of basic and social emotions, social and personal behaviour, sensory behaviour, eating and oral behaviour, repetitive behaviours, rituals, and compulsions, was administered to carers of 41 patients with semantic dementia and with apathetic (FTD-A) and disinhibited (FTD-D) forms of frontotemporal dementia.Results-Consistent with prediction, emotional changes differentiated FTD from semantic dementia. Whereas lack of emotional response was pervasive in FTD, it was more selective in semantic dementia, affecting particularly the capacity to show fear. Social avoidance occurred more often in FTD and social seeking in semantic dementia. Patients with FTD showed reduced response to pain, whereas patients with semantic dementia more often showed exaggerated reactions to sensory stimuli. Gluttony and indiscriminate eating were characteristic of FTD, whereas patients with semantic dementia were more likely to exhibit food fads. Hyperorality, involving inedible objects, was unrelated to gluttony, indicating different underlying mechanisms. Repetitive behaviours were common in both FTD and semantic dementia, but had a more compulsive quality in semantic dementia. Behavioural differences were greater between semantic dementia and FTD-A than FTD-D. A logistic regression analysis indicated that emotional and repetitive, compulsive behaviours discriminated FTD from semantic dementia with 97% accuracy.Conclusion-The findings confirm predictions regarding behavioural differences in frontotemporal and semantic dementia and point to differential roles of the frontal and temporal lobes in affect, social functioning, eating, and compulsive behaviour.