Homoleptic Lanthanide Amide Catalysts for Organic Synthesis: Experiment and Theory
Homoleptic Lanthanide Amide Catalysts for Organic Synthesis: Experiment and Theory
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DOI：
10.1021/acscatal.0c04882
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发表时间：
2021-02-12
期刊：
影响因子：
12.9
通讯作者：
Marks, Tobin J.
中科院分区：
文献类型：
--
作者：
Dicken, Rachel D.;Motta, Alessandro;Marks, Tobin J.
同配型镧系元素三酰胺在有机镧系元素化学和合成方法学社区之间提供了一个简单且高度可及的桥梁，尽管它们已被证明在各种独特的转化中是胜任的催化剂，但相对于镧系元素三烯和相关的有机金属催化剂，它们的反应性、范围和机制仍然研究不足。在这个角度来看，我们提供了一个关键的审查最近的进展均配镧系元素介导的催化，因为它们适用于原子效率和环境友好的有机合成。而不是一个详尽的审查，我们专注于选择的例子，意想不到的反应显示容易获得的Ln[N（SiMe 3）（2）]（3）配合物。通过关注这项工作的实验以及理论和机理方面，我们试图强调均配镧系元素酰胺不寻常催化性能的价值、多功能性和基本概念，并对该领域的前景提供总体展望。
Homoleptic lanthanide trisamides provide a simple and highly accessible bridge between organolanthanide chemistry and the synthetic methodology community, and although they have proven to be competent catalysts in a wide variety of unique transformations, their reactivity, scope, and mechanism remain understudied relative to lanthanide metallocenes and related organometallic catalysts. In this Perspective, we provide a critical review of the recent advances in homoleptic lanthanide-mediated catalysis as they apply to atom-efficient and environmentally benign organic syntheses. Instead of an exhaustive review, we focus on selected examples of the unexpected reactivity displayed by readily available Ln[N(SiMe3)(2)](3) complexes. By focusing on both the experimental as well as theoretical and mechanistic aspects of this work, we seek to highlight the value, versatility, and underlying concepts governing the unusual catalytic properties of homoleptic lanthanide amides and offer a general outlook on the prospects for this field.