Effects of naloxone on cardiovascular responses to static exercise and behavior in conscious cats.
Effects of naloxone on cardiovascular responses to static exercise and behavior in conscious cats.
复制标题
纳洛酮对清醒猫静态运动和行为的心血管反应的影响。
DOI：
10.1016/0031-9384(87)90177-6
复制
发表时间：
1987
影响因子：
2.9
通讯作者：
Geldon,D
中科院分区：
文献类型：
--
作者：
Waldrop,TG;Bielecki,M;Geldon,D
Conscious cats performing static (isometric) exercise were studied before and after administration of the opiate antagonist naloxone in order to evaluate the possible role of endogenous opiates in regulating cardiovascular responses to static exercise. Intravenous administration (0.4 mg/kg) of naloxone had no effect on resting left ventricular systolic pressure or on heart rate. In addition, similar increases in left ventricular systolic pressure and heart rate occurred during static exercise both before and after naloxone. However, naloxone reduced the number of exercise events the cats would perform per day. We conclude that moderate doses of naloxone do not modulate the cardiovascular responses to moderate static exercise in conscious cats. The results do indicate that endogenous opiates are involved in regulating the number of exercise bouts the cats will perform per day.
