The hippocampus encodes delay and value information during delay-discounting decision making
The hippocampus encodes delay and value information during delay-discounting decision making
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DOI：
10.1101/495598
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发表时间：
2018-12
期刊：
影响因子：
7.7
通讯作者：
Akira Masuda;Chie Sano;Qi Zhang;Hiromichi Goto;T. McHugh;Shigeyoshi Fujisawa;S. Itohara
中科院分区：
文献类型：
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作者：
Akira Masuda;Chie Sano;Qi Zhang;Hiromichi Goto;T. McHugh;Shigeyoshi Fujisawa;S. Itohara
海马体，一个对记忆和空间导航至关重要的区域，被认为与延迟折扣有关，即当施加延迟时主观奖励价值的下降。然而，延迟贴现是如何在海马体中编码的，人们知之甚少。在这里，我们记录了执行延迟折扣决策任务的小鼠的海马CA1区域，其中延迟长度和奖励数量在会议期间发生变化，并确定了CA1神经元亚群，这些神经元亚群在长时间延迟期间增加或减少了放电率。延迟激活细胞和延迟抑制细胞的活动都反映延迟长度、奖励量和手臂位置，但操纵奖励量对两种群体的影响不同，表明在评估过程中起着不同的作用。此外，海马锥体细胞中NMDA受体的基因缺失会损害延迟折扣行为，并降低CA1的延迟依赖性活性。我们的研究结果表明，海马神经元的不同亚类以依赖于NMDA受体功能的方式共同支持延迟贴现决策。
The hippocampus, a region critical for memory and spatial navigation, has been implicated in delay discounting, the decline in subjective reward value when a delay is imposed. However, how delay discounting is encoded in the hippocampus is poorly understood. Here we recorded from the hippocampal CA1 region of mice performing a delay-discounting decision-making task, where delay lengths and reward amounts were changed across sessions, and identified subpopulations of neurons in CA1 which increased or decreased their firing rate during long delays. The activity of both delay-active and -suppressive cells reflected delay length, reward amount, and arm position, however manipulating reward amount differentially impacted the two populations, suggesting distinct roles in the valuation process. Further, genetic deletion of NMDA receptor in hippocampal pyramidal cells impaired delay-discount behavior and diminished delay-dependent activity in CA1. Our results suggest that distinct subclasses of hippocampal neurons concertedly support delay-discounting decision in a manner dependent on NMDA receptor function.