Reappearance of influenza B/Victoria/2/87-lineage viruses:: epidemic activity, genetic diversity and vaccination efficacy in the Finnish Defence Forces
Reappearance of influenza B/Victoria/2/87-lineage viruses:: epidemic activity, genetic diversity and vaccination efficacy in the Finnish Defence Forces
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DOI：
10.1017/s0950268804003462
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发表时间：
2005-04-01
影响因子：
4.2
通讯作者：
Korpela, H
中科院分区：
文献类型：
--
作者：
Ikonen, N;Pyhälä, R;Korpela, H
一种新的B/Shangdong/7/97样流感病毒（维多利亚/2/87谱系）在芬兰2002/2003流行季节占主导地位，据估计，在芬兰军队应征入伍者中发生的13496例发热性上呼吸道感染（URI）中，有2246例是由该病毒引起的。发病率（1716/10000义务兵）是中度流行病活动的指示。对1988年诱导的交叉反应性抗体的分析表明，保护的基础可能是在应征入伍者的童年时期建立的。2002年秋季的疫苗接种预防了B型流感爆发期间42%的URI和71%（95% CI 42-85）的解释为B型流感的感染。尽管山东/7/97-样病毒的遗传变异性低，在血凝素（HA 1，位置197）的一个潜在的糖基化位点的断裂是频繁的，其生物学意义进行了讨论。山东/7/97型菌株是HA 1/NA的耐药株，而HA 1型菌株中丰度较低的菌株属于B/Yamagata/16/88谱系。进一步的重组，这可能出现在爆发期间的一个驻军，支持我们的假设，在这些设置的情况下，可能特别有利于通过重组的多样性的出现。
A new B/Shangdong/7/97-like influenza virus (Victoria/2/87 lineage) predominated during the 2002/2003 epidemic season in Finland and was estimated to account for 2246 of the 13 496 feverish upper respiratory tract infections (URIs) occurring among conscripts in the Finnish army. The incidence (1716/10000 conscripts) was indicative of moderate epidemic activity at most. Analysis of the cross-reactive antibodies induced in 1988 suggests that the basis of the protection was probably established during the childhood of the conscripts. Vaccination in autumn 2002 prevented 42 % of the URIs during the influenza B outbreak and 71 % (95 % CI 42-85) of infections interpreted as influenza B. Despite the low genetic variability of the Shangdong/7/97-like viruses, breakages of a potential glycosylation site in haemagglutinin (HA1, position 197) were frequent; their biological significance is discussed. The Shangdong/7/97-like strains were HA1/NA reassortants, as were also the less abundant strains that for HA1 belonged to the B/Yamagata/16/88 lineage. A further reassortment, which probably emerged during the outbreak in one of the garrisons, supports our hypothesis that circumstances in these settings may especially favour the emergence of diversity by reassortment.