A putative telomerase activator has tissue‐specific effects on telomere length in a developing songbird
A putative telomerase activator has tissue‐specific effects on telomere length in a developing songbird
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DOI：
10.1111/jav.02639
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发表时间：
2020-08
影响因子：
1.7
通讯作者：
Sarah E. Wolf;K. R. Stansberry;Kristen R. Content;K. Rosvall
中科院分区：
文献类型：
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作者：
Sarah E. Wolf;K. R. Stansberry;Kristen R. Content;K. Rosvall
有很好的证据表明，端粒预测健康和寿命的变化，但目前还不清楚这些模式是否因果关系来自端粒本身，部分原因是相对较少的研究直接操纵端粒长度在生命早期，当端粒缩短是最动态的。在这里，我们测试了端粒酶激活剂TA-65（即环星形胶质醇）如何影响野生树燕Tachycineta bicolor生长高峰期五种组织中的端粒长度。经口给予TA-65 8天后，雏鸡血液中的端粒延长，羽毛生长加速，但质量随时间推移无变化。TA-65不影响大脑或脾脏中的端粒长度，并导致肝脏和肾上腺中的端粒缩短。因此，这种端粒动力学的整体生物实验操作揭示了端粒保护和生物衰老的局限性。在这样做的过程中，这项工作推进了我们对早期生命端粒动力学及其在产生未来健康和寿命变化中的潜在作用的理解。
There is good evidence that telomeres predict variation in health and longevity, yet it is unclear whether these patterns are causally derived from telomeres per se, in part because relatively little research directly manipulates telomere length during early life, when telomere shortening is most dynamic. Here, we test how the telomerase activator TA‐65 (i.e. cycloastrogenol) affects telomere length in five tissues during the peak of growth in the wild tree swallowTachycineta bicolor. Following eight days of oral TA‐65 administration, chicks experienced telomere lengthening in the blood and accelerated feather growth, but no changes to mass over time. TA‐65 did not affect telomere length in the brain or spleen and led to shorter telomeres in the liver and adrenals. This whole‐organism experimental manipulation of telomere dynamics therefore reveals limitations to telomere protection and biological senescence. In doing so, this work advances our understanding of early‐life telomere dynamics and their potential role in generating future variation in health and lifespan.