Strategy for uncovering complex determinants of hypertension using animal models.
Strategy for uncovering complex determinants of hypertension using animal models.
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DOI：
10.1007/s11906-000-0085-0
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发表时间：
2000-04-01
影响因子：
5.6
通讯作者：
Cicila, G T
中科院分区：
文献类型：
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作者：
Cicila, G T
高血压是一种复杂的多因素疾病，是多种遗传和环境因素相互作用造成的。虽然高血压啮齿动物模型已被证明可用于识别包含血压数量性状基因座（QTL）的染色体区域，但导致血压应变差异的基因仍有待确定。提出了一种在动物模型中识别血压遗传因素的策略，根据以下主题分组：1）高血压模型的选择，2）识别包含QTL的染色体区域，3）确认QTL的存在并界定包含它们的染色体区域，4）开发染色体上包含QTL区域的物理图谱，5）识别强候选者 基因，以及 6) 证明基因在一定程度上造成血压差异的要求。
Hypertension is a complex, multifactorial disorder resulting from the interaction of multiple genetic and environmental factors. While rodent models of hypertension have proved useful for identifying chromosomal regions containing blood pressure quantitative trait loci (QTLs), the gene(s) responsible for strain-differences in blood pressure remain to be identified. A strategy for identifying the genetic factors underlying blood pressure in animal models is presented, grouped according to the following themes: 1) choice of hypertension model, 2) identification of chromosomal regions containing QTLs, 3) confirming the presence of QTLs and delimiting the chromosomal region containing them, 4) developing a physical map of the QTL-containing region of the chromosome, 5) identification of strong candidate gene(s), and 6) requirements for proving that a gene is responsible, in part, for blood pressure differences.