Sex and genetic effects on upper and lower body fat and associations with diabetes in multigenerational families of African heritage
Sex and genetic effects on upper and lower body fat and associations with diabetes in multigenerational families of African heritage
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DOI：
10.1016/j.metabol.2008.01.022
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发表时间：
2008-06-01
影响因子：
9.8
通讯作者：
Zmuda, Joseph M.
中科院分区：
文献类型：
--
作者：
Miljkovic-Gacic, Iva;Wang, Xiaojing;Zmuda, Joseph M.
很少有研究全面定义遗传和环境对手臂和腿部脂肪储存的影响及其与糖尿病的关系，特别是在非洲血统的家庭中。我们通过双能 X 射线吸收测定法（总脂肪百分比、躯干脂肪百分比、手臂脂肪百分比和腿部脂肪百分比）和空腹血糖分析了来自 8 个多代非裔加勒比家庭（平均家庭规模 = 51；3535 个亲属对）的 471 名个体（平均年龄 43 岁）的身体脂肪分布。糖尿病与腿部脂肪百分比呈负相关 (P=.009)，并且在某种程度上与腿部脂肪百分比呈正相关，与年龄、性别和体型无关 (P=.08)，但与人体测量或双能 X 射线吸收测量的总脂肪和中心脂肪无关。此外，腿部脂肪百分比与体重指数、腰围和血糖呈负相关，而腿部脂肪百分比呈正相关（P
Very few studies have comprehensively defined the genetic and environmental influences on body fat storage in the arms and legs and their association with diabetes, especially in families of African heritage. We analyzed body fat distribution by dual-energy x-ray absorptiometry (percentage total fat, percentage trunk fat, percentage arm fat, and percentage leg fat) and fasting serum glucose in 471 individuals (mean age, 43 years) from 8 multigenerational Afro-Caribbean families (mean family size = 51; 3535 relative pairs). Diabetes was inversely associated with percentage leg fat (P=.009) and, to some extent, positively associated with percentage ann fat independent of age, sex, and body size (P=.08), but not with anthropometric or dual-energy x-ray absorptiometric measures of total and central adiposity. Furthermore, percentage leg fat was inversely, whereas percentage ann fat was positively, associated with body mass index, waist circumference, and serum glucose (P