Astrocytic purinergic signaling coordinates synaptic networks
Astrocytic purinergic signaling coordinates synaptic networks
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DOI：
10.1126/science.1116916
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发表时间：
2005-10-07
期刊：
影响因子：
56.9
通讯作者：
Haydon, PG
中科院分区：
文献类型：
--
作者：
Pascual, O;Casper, KB;Haydon, PG
为了研究星形胶质细胞在调节突触传递中的作用，我们产生了诱导型转基因小鼠，其选择性地在星形胶质细胞中表达显性负性SNARE结构域以阻断从这些胶质细胞释放递质。通过释放腺苷三磷酸（其积累为腺苷），星形胶质细胞紧张性抑制突触传递，从而增强长时程增强和介导的活性依赖性异突触抑制的动态范围。这些结果表明，星形胶质细胞在突触强度和可塑性的调节中错综复杂地联系在一起，并为突触串扰提供了一条途径。
To investigate the rote of astrocytes in regulating synaptic transmission, we generated inducible transgenic mice that express a dominant-negative SNARE domain selectively in astrocytes to block the release of transmitters from these glial cells. By releasing adenosine triphosphate, which accumulates as adenosine, astrocytes tonically suppressed synaptic transmission, thereby enhancing the dynamic range for long-term potentiation and mediated activity-dependent, heterosynaptic depression. These results indicate that astrocytes are intricately linked in the regulation of synaptic strength and plasticity and provide a pathway for synaptic cross-talk.