Cerebrospinal fluid pentraxin 3 and CD40 ligand in anti-N-menthyl-D-aspartate receptor encephalitis
Cerebrospinal fluid pentraxin 3 and CD40 ligand in anti-N-menthyl-D-aspartate receptor encephalitis
复制标题
抗 N-薄荷基-d-天冬氨酸受体脑炎中的脑脊液五聚蛋白 3 和 CD40 配体
DOI：
10.1016/j.jneuroim.2017.11.016
复制
发表时间：
2018-02-15
影响因子：
3.3
通讯作者：
Wang, Honghao
中科院分区：
文献类型：
--
作者：
Liu, Baozhu;Ai, Peiying;Wang, Honghao
抗n -甲基- d -天冬氨酸受体（NMDAR）脑炎是一种中枢神经系统自身免疫性疾病，其发病机制与白细胞介素(IL)-6和IL- 17a有关。我们检测了抗nmdar脑炎患者脑脊液急性期戊烷素3 （PTX3）、慢性炎症介质CD40L、IL-6和IL-17A浓度的相关性及其对临床结果的影响。抗nmdar脑炎患者脑脊液中PTX3、CD40L、IL-6、IL-17A含量明显高于对照组。在前者中，PTX3水平与IL-6和mRS呈正相关，CD40L水平与IL-17A和mRS呈正相关。PTX3和CD40L水平升高可能反映了潜在的神经炎症。
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder of the central nervous system whose pathogenesis involves interleukin (IL)-6 and IL-17A. We examined the correlations between CSF concentrations of the acute-phase protein pentraxin 3 (PTX3), the chronic inflammatory mediator CD40L, IL-6, and IL-17A in anti-NMDAR encephalitis, and the impact on clinical outcome. PTX3, CD40L, IL-6, and IL-17A were significantly higher in the CSF of patients with anti-NMDAR encephalitis than in controls. Within the former, PTX3 levels correlated positively with IL-6 and the mRS, and CD40L levels with IL-17A and the mRS. Higher PTX3 and CD40L levels may reflect the underlying neuroinflammation.