Lisinopril dose-response relationship in essential hypertension.
Lisinopril dose-response relationship in essential hypertension.
复制标题
原发性高血压赖诺普利的剂量-反应关系。
DOI：
10.1111/j.1365-2125.1989.tb03521.x
复制
发表时间：
1989
影响因子：
3.4
通讯作者：
E. Maccarthy
中科院分区：
文献类型：
--
作者：
H. Gomez;V. Cirillo;J. A. Sromovsky;E. S. Otterbein;W. Shaw;J. Rush;S. Chrysant;A. Gradman;A. Leon;E. Maccarthy
1. 这是一项多中心、双盲、平行研究，纳入了216例轻中度（仰卧舒张压= 95-115 mm Hg）原发性高血压患者。2. 在4周安慰剂洗脱期后，患者被随机分配到安慰剂组或赖诺普利1.25、5.20或80 mg组，每天一次，连续6周。在给药后第2周、第0周、第2周、第4周和第6周结束时测量仰卧和直立血压。3. 仰卧和直立血压呈线性剂量-反应关系。赖诺普利20和80 mg day-1组的舒张压降低明显大于安慰剂组或赖诺普利1.25和5 mg day-1组。4. 赖诺普利的剂量高达80mg， day-1，耐受性良好。
1. This was a multicentre, double-blind, parallel study in 216 patients with mild to moderate (supine diastolic blood pressure = 95-115 mm Hg) essential hypertension. 2. After a 4-week placebo washout, patients were randomized to placebo or lisinopril 1.25, 5.20 or 80 mg once daily for 6 consecutive weeks. Supine and erect blood pressure was measured 24 h postdose at the end of weeks -2, 0, 2, 4, and 6. 3. There was a linear dose-response relationship for both supine and erect blood pressure. Diastolic blood pressure reductions in the lisinopril 20 and 80 mg day-1 groups were significantly greater than in the placebo or lisinopril 1.25 and 5 mg day-1 groups. 4. Lisinopril, at doses up to 80 mg day-1, was well tolerated.