The Y of cancer sex differences.
The Y of cancer sex differences.
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DOI：
10.1002/ctm2.1402
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发表时间：
2023-09
影响因子：
10.6
通讯作者：
中科院分区：
文献类型：
--
作者：
In mammals, the Y chromosome (chrY) determines the male sex and maintains secondary sex characteristics including spermatogenesis. But does the chrY participate in additional biological functions? The answer is a definitive yes. Recent studies have re-examined the onceconsidered “genetic wasteland” chromosome, identifying its role in human cancer biology. The chrY is largely heterochromatic and extremely gene-poor. 1 There are approximately 58 million base pairs on chrY, which is one-third the size of the X chromosome. Excluding the heterochromatin and pseudogenes, chrY possesses a meager 50 protein-coding genes. Among them, nearly half are expressed solely in the testis, while another half are expressed ubiquitously or at least in multiple organs, 2 suggesting physiological functions in somatic tissues. The most well-known chrY gene is the sexdetermining region Y protein (SRY). SRY encodes a transcription factor, the expression of which causes testis formation in early development. Many other chrY genes are also involved in spermatogenesis and male fertility, including DDX3Y, PCDH11Y and DAZ. 3, 4 Besides their sexual functions, DDX3Y also encodes an MHC-I male-specific minor histocompatibility (HY) antigen in leukemic stem cells 5 and PCDH11Y is related to autism. 6 Two ubiquitously expressed chrY genes, KDM5D (also called
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影响因子：
2.7
作者：
Nardello R;Antona V;Mangano GD;Salpietro V;Mangano S;Fontana A
通讯作者：
Fontana A
影响因子：
1.9
作者：
Anilkumar, Thottathil R.;Devi, Anandavalli N.;Kumar, Pradeep G.
通讯作者：
Kumar, Pradeep G.
影响因子：
4
作者：
Lardone, M. C.;Parodi, D. A.;Castro, A.
通讯作者：
Castro, A.
影响因子：
20.3
作者：
Rosinski, Kellie V.;Fujii, Nobuharu;Warren, Edus H.
通讯作者：
Warren, Edus H.
影响因子：
64.8
作者：
Lan, Fei;Bayliss, Peter E.;Shi, Yang
通讯作者：
Shi, Yang