Beat-to-beat Estimation of Peripheral Arterial Stiffness from Local PWV for Quantitative Evaluation of Sympathetic Nervous System Activity
Beat-to-beat Estimation of Peripheral Arterial Stiffness from Local PWV for Quantitative Evaluation of Sympathetic Nervous System Activity
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DOI：
10.1109/tbme.2022.3154398
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发表时间：
2022-02
影响因子：
4.6
通讯作者：
Ziqiang Xu;Toshiki Sakagawa;A. Furui;Shumma Jomyo;M. Morita;Masamichi Ando;T. Tsuji
中科院分区：
文献类型：
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作者：
Ziqiang Xu;Toshiki Sakagawa;A. Furui;Shumma Jomyo;M. Morita;Masamichi Ando;T. Tsuji
交感神经系统活动（SNSA）可以快速调节动脉僵硬度，因此使其成为SNSA评估的重要生物标志物。脉搏波速度（PWV）是一个众所周知的动脉僵硬度的定量指标，但其功能的SNSA反应尚未阐明。本文报告了一种方法来估计快速变化的外周动脉僵硬度引起的SNSA使用本地PWV（LPWV），并进一步量化SNSA的基础上估计的刚度。在皮肤电刺激实验中，使用可生物降解的压电传感器和光电体积描记传感器测量从手腕附近的动脉到食指附近的动脉的LPWV，其中疼痛指示SNSA。量化了LPWV、同时测量的外周动脉僵硬指数和自我报告的疼痛强度之间的关系。LPWV单独估计的硬度和LPWV和动脉压估计的硬度都接近外周动脉硬度指数（R2 = 0.9775和0.9719）。疼痛强度可以通过基于单独LPWV的估计刚度（r = 0.8594）或基于LPWV和动脉压的估计刚度（r = 0.9738）以S形关系定量评估。我们的研究结果证明了LPWV在SNSA定量评估中的有效性以及根据应用场景进行血压校正的可选性。本研究通过LPWV的交感神经反应性促进了对外周动脉交感神经支配的理解，并为SNSA评估提供了定量生物标志物。
Sympathetic nervous system activity (SNSA) can rapidly modulate arterial stiffness, thus making it an important biomarker for SNSA evaluation. Pulse wave velocity (PWV) is a well-known quantitative indicator of arterial stiffness, but its functional responsivity to SNSA has not been elucidated. This paper reports a method to estimate rapid changes in peripheral arterial stiffness induced by SNSA using local PWV (LPWV) and to further quantify SNSA based on the estimated stiffness. LPWV was measured from the artery near the wrist to the artery near the forefinger using a biodegradable piezoelectric sensor and a photoplethysmography sensor in an electrocutaneous stimulus experiment in which pain indicts the SNSA. The relationship between LPWV, simultaneously measured peripheral arterial stiffness index, and self-reported pain intensity was quantified. The stiffness estimated by LPWV alone and the stiffness estimated by LPWV and arterial pressure both approximate the peripheral arterial stiffness index (R2 = 0.9775 and 0.9719). Pain intensity can be quantitatively evaluated in a sigmoidal relationship by either the estimated stiffness based on LPWV alone (r = 0.8594) or the estimated stiffness based on LPWV and arterial pressure (r = 0.9738). Our results demonstrated the validity of LPWV in the quantitative evaluation of SNSA and the optionality of blood pressure correction depending on application scenarios. This study advances the understanding of sympathetic innervation of peripheral arteries through the sympathetic responsivity of LPWV and contributes a quantitative biomarker for SNSA evaluation.