DETERMINATION OF TYPE-I RECEPTOR SPECIFICITY BY THE TYPE-II RECEPTORS FOR TGF-BETA OR ACTIVIN
DETERMINATION OF TYPE-I RECEPTOR SPECIFICITY BY THE TYPE-II RECEPTORS FOR TGF-BETA OR ACTIVIN
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DOI：
10.1126/science.8235612
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发表时间：
1993-11-05
期刊：
影响因子：
56.9
通讯作者：
DERYNCK, R
中科院分区：
文献类型：
--
作者：
EBNER, R;CHEN, RH;DERYNCK, R
转化生长因子-β（TGF-β）和激活素主要通过与I型和II型受体相互作用来发出信号，所述I型和II型受体是跨膜丝氨酸-苏氨酸激酶。Tsk 7 L是TGF-β的I型受体，并且需要共表达II型TGF-β受体用于配体结合。当与IIA型激活素受体共表达时，Tsk 7 L也特异性结合激活素。Tsk 7 L可与两种II型受体结合，并具有与II型受体结合的特异性。因此，Tsk 7 L可以作为激活素和TGF-β以及可能的其他配体的I型受体。
Transforming growth factor-beta (TGF-beta) and activin signal primarily through interaction with type I and type II receptors, which are transmembrane serine-threonine kinases. Tsk 7L is a type I receptor for TGF-beta and requires coexpression of the type II TGF-beta receptor for ligand binding. Tsk 7L also specifically bound activin, when coexpressed with the type IIA activin receptor. Tsk 7L could associate with either type II receptor and the ligand binding specificity of Tsk 7L was conferred by the type II receptor. Tsk 7L can therefore act as type I receptor for both activin and TGF-beta, and possibly other ligands.