Amphetamine locomotor sensitization and conditioned place preference in adolescent male and female rats neonatally treated with quinpirole
Amphetamine locomotor sensitization and conditioned place preference in adolescent male and female rats neonatally treated with quinpirole
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DOI：
10.1097/fbp.0b013e328348737b
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发表时间：
2011-08-01
影响因子：
1.6
通讯作者：
Smith, Meredith L.
中科院分区：
文献类型：
--
作者：
Brown, Russell W.;Perna, Marla K.;Smith, Meredith L.
新生儿喹吡罗治疗已被证明会增加多巴胺D（2）样受体的敏感性，并持续整个受试者的一生。目的是使用运动敏化和条件性位置偏爱程序分析新生大鼠喹吡罗治疗对青春期大鼠苯丙胺效应的影响。Sprague-Dawley大鼠从出生后第1天（P）至P11天接受喹吡罗（1 mg/kg）或生理盐水治疗，并饲养至青春期。对于自发致敏，受试者从P35至P47每隔一天给予安非他明（1 mg/kg）或盐水，并置于自发竞技场。在雌性大鼠中，与对苯丙胺致敏的无喹吡罗对照组相比，新生儿喹吡罗治疗增强了苯丙胺运动致敏。雄性大鼠表现出对苯丙胺的敏感性，尽管与雌性大鼠相比，这是无声的，并且不受新生儿喹吡罗的影响。对于条件性位置偏好，受试者连续8天（P32-39）接受安非他明（1 mg/kg）或生理盐水条件化，并在P40进行无药物偏好测试。与无喹吡罗的对照组相比，用新生大鼠喹吡罗治疗的大鼠在安非他明配对环境中花费的时间增加，但与盐水治疗的对照组相比，只有用安非他明治疗的雌性对照组在药物配对环境中花费的时间更多。D（2）样受体敏感性的增加似乎增强了安非他明的行为影响，但与雄性大鼠相比，这些影响在青春期雌性大鼠中更为普遍。行为药理学22：374-378（C）2011年威科健康垂直酒吧Lippincott威廉姆斯&威尔金斯。
Neonatal quinpirole treatment has been shown to produce an increase in dopamine D(2)-like receptor sensitivity that persists throughout the subject's lifetime. The objective was to analyze the effects of neonatal quinpirole treatment on effects of amphetamine in adolescent rats using locomotor sensitization and conditioned place preference procedures. Sprague-Dawley rats were treated with quinpirole (1 mg/kg) or saline from postnatal days (P) 1 to P11 and raised to adolescence. For locomotor sensitization, subjects were given amphetamine (1 mg/kg) or saline every second day from P35 to P47 and were placed into a locomotor arena. In female rats, neonatal quinpirole treatment enhanced amphetamine locomotor sensitization compared with quinpirole-free controls sensitized to amphetamine. Male rats demonstrated sensitization to amphetamine, although this was muted compared with female rats, and were unaffected by neonatal quinpirole. For conditioned place preference, subjects were conditioned for 8 consecutive days (P32-39) with amphetamine (1 mg/kg) or saline and a drug-free preference test was conducted at P40. Rats treated with neonatal quinpirole enhanced time spent in the amphetamine-paired context compared with quinpirole-free controls conditioned with amphetamine, but only female controls conditioned with amphetamine spent more time in the drug-paired context compared with saline-treated controls. Increased D(2)-like receptor sensitivity appears to have enhanced the behavioral effects of amphetamine, but these effects were more prevalent in adolescent female rats compared with male rats. Behavioural Pharmacology 22: 374-378 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.