The expression status of CD133 is associated with the pattern and timing of primary glioblastoma recurrence
The expression status of CD133 is associated with the pattern and timing of primary glioblastoma recurrence
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DOI：
10.1093/neuonc/not066
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发表时间：
2013-09-01
期刊：
影响因子：
15.9
通讯作者：
Tominaga, Teiji
中科院分区：
文献类型：
--
作者：
Shibahara, Ichiyo;Sonoda, Yukihiko;Tominaga, Teiji
胶质母细胞瘤的预后很差，主要是因为它的高复发率。预测复发模式和时间的能力对于确定有效的治疗策略将是非常有用的。我们研究了原发性胶质母细胞瘤患者的预后因素与复发模式之间的相关性。特别是，我们研究了CD133的表达与胶质母细胞瘤复发之间是否存在相关性。从医疗记录中获得初始复发的时间和模式（局部或远处）。为了确定复发的预测因素，我们通过免疫印迹和免疫组化检测了CD133的表达，包括临床因素（年龄、性别、KPS、Ki 67标记指数、手术、入心室）和遗传因素（IDH1、7p、9p、10q、MGMT）。首次复发为局部复发77例，远处复发22例。在预测复发模式的因素中，远处复发的CD 133表达显著高于局部复发。在预测复发时间的因素中，在单变量和多变量分析中，高CD 133表达与较短的远处复发时间相关（分别为P 0.0011和P 0.038）。CD 133表达可能是原发性胶质母细胞瘤复发模式和时间的预测因子。
Glioblastoma carries a poor prognosis primarily because of its high rate of recurrence. The ability to predict the recurrence pattern and timing would be highly useful for determining effective treatment strategies. We examined the correlation between prognostic factors and the pattern of recurrence in patients with primary glioblastoma. In particular, we examined whether there was a correlation between the expression of CD133 and glioblastoma recurrence.We retrospectively analyzed 112 patients with primary glioblastoma. The timing and pattern (local or distant) of the initial recurrence were obtained from medical records. To identify factors predictive of recurrence, we examined CD133 expression by Western blots and immunohistochemistry, clinical (age, sex, KPS, Ki67 labeling index, surgery, ventricular entry) and genetic (IDH1, 7p, 9p, 10q, MGMT) factors.Of the 112 patients, 99 suffered recurrence. The first recurrence was local in 77 patients and distant in 22 patients. Among the factors to predict the pattern of recurrence, CD133 expression was significantly higher in distant than in local recurrence. Of the factors to predict the timing of recurrence, high CD133 expression was associated with shorter time to distant recurrence in both univariate and multivariate analyses (P .0011 and P .038, respectively).The expression of CD133 may be a predictor of the pattern and timing of recurrence of primary glioblastoma.