Genome-wide methylation profiling demonstrates hypermethylation in maternal leukocyte DNA in preeclamptic compared to normotensive pregnancies.
Genome-wide methylation profiling demonstrates hypermethylation in maternal leukocyte DNA in preeclamptic compared to normotensive pregnancies.
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DOI：
10.3109/10641955.2013.796970
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发表时间：
2013-08
影响因子：
1.5
通讯作者：
Garovic VD
中科院分区：
文献类型：
--
作者：
White WM;Brost B;Sun Z;Rose C;Craici I;Wagner SJ;Turner ST;Garovic VD
目的：比较正常血压和先兆子痫孕妇分娩时外周血白细胞DNA全基因组甲基化情况。14,495个基因中27,578个胞嘧啶-鸟嘌呤基因甲基化与年龄、体重指数相匹配的病例-对照比较显示，先兆子痫(PE；n=14)和正常血压对照组(n=14)的孕妇外周血白细胞DNA中胞嘧啶-鸟嘌呤基因甲基化水平存在差异。PE与普遍存在的有利于高甲基化的差异甲基化有关。通路分析表明，最佳匹配过程为神经肽信号通路(p<；10−5)；最佳匹配疾病为子痫(p<；9.97×10−20)。显著差异甲基化基因(GRIN2B.GABRA1.PCDHB7和BEX1)与癫痫有关。母亲白细胞DNA甲基化改变与分娩时的PE有关，某些神经元基因的差异甲基化可能解释了子痫的风险。
To compare genome-wide methylation profiles in maternal leukocyte DNA between normotensive and preeclamptic pregnant women at delivery. Age, body mass index matched case-control comparison of methylation at 27,578 cytosine—guanine sites in 14,495 genes in maternal leukocyte DNA in women with preeclampsia (PE; n = 14) and normotensive controls (n = 14). PE was associated with widespread differential methylation favoring hypermethylation. Pathway analysis identified the best matched process as a neuropeptide signaling pathway (p < 10−5); best matched disease as eclampsia (p < 9.97 × 10−20). Significantly differentially methylated genes (GRIN2b. GABRA1. PCDHB7, and BEX1) are associated with seizures. Altered maternal leukocyte DNA methylation is associated with PE at delivery, and differential methylation of certain neuronal genes may explain the risk for eclampsia.
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影响因子：
3.7
作者：
Yuen RK;Avila L;Peñaherrera MS;von Dadelszen P;Lefebvre L;Kobor MS;Robinson WP
通讯作者：
Robinson WP
人胎盘中 COMT 启动子低甲基化与先兆子痫的发生无关
影响因子：
4
作者：
Zhao, Arman;Cheng, Yan;Zhao, Xinzhi
通讯作者：
Zhao, Xinzhi
影响因子：
3.1
作者：
Kulkarni, Asmita;Chavan-Gautam, Preeti;Joshi, Sadhana
通讯作者：
Joshi, Sadhana
DOI：
10.1038/nrg3000
发表时间：
2011-07-12
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.7
作者：
Bell CG;Teschendorff AE;Rakyan VK;Maxwell AP;Beck S;Savage DA
通讯作者：
Savage DA